Sep 1, 1986

Ionophore A23187 stimulates arachidonic acid release and cyclic GMP accumulation in pig epidermis

The British Journal of Dermatology
N KatoK M Halprin


We studied the effect of Ionophore A23187 (A23187) on phospholipid degradation and the accumulation of cyclic GMP in pig epidermis. A23187 stimulated the release of AA, probably partially through the activation of phospholipase A2. A23187 also stimulated the accumulation of epidermal cyclic GMP, but the activity of cyclic GMP-dependent phosphodiesterases was not altered. Mepacrine, an inhibitor of phospholipase A2, inhibited the A23187-stimulated accumulation of cyclic GMP. The results suggest that A23187 stimulates the accumulation of epidermal cyclic GMP by a calcium-dependent process which also requires products of phospholipid degradation.

  • References10
  • Citations1


  • References10
  • Citations1


Mentioned in this Paper

Calcium [EPC]
Phospholipase A2, human
Phospholipid Catabolism
Cyclic GMP Measurement (Lab Test)
Arachidonic Acid
Phosphoric diester hydrolase
Epidermitis, Exudative, of Swine
Culture Techniques

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