Ionophore and arachidonic acid stimulation of airway responses in rhesus monkeys

The Journal of Clinical Investigation
R PattersonP A Greenberger

Abstract

Aerosolized doses of the ionophore, A23187, and arachidonic acid individually resulted in no airway response in rhesus monkeys. When these two agents were given simultaneously, by aerosol, an airway response occurred. The pulmonary function abnormalities that occurred qualitatively simulated those of an antigen-induced airway response. This is the first demonstration in our laboratory of two agents which singly will not produce a response but which are reactive when delivered in combination. Other fatty acids did not produce a similar response. The response to A23187 and arachidonic acid occurred only in rhesus monkeys from our colony which had been demonstrated to have airway responses to aerosolized antigen challenge, a response shown previously to be associated with hyperreactive airways to pharmacologic stimuli. The A23187 and arachidonic acid response was inhibited by aerosolized 5,8,11,14-eicosatetraynoic acid, an inhibitor of the cyclooxygenase and lipoxygenase pathways of arachidonic acid metabolism. Further, indomethacin, a prostaglandin synthetase inhibitor of the cyclooxygenase pathway, inhibited the response, although previous studies showed that this drug will potentiate an antigen-induced response in this animal m...Continue Reading

References

Oct 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·B A JakschikC W Parker
Sep 1, 1978·The Journal of Clinical Investigation·R PattersonK E Harris
Jun 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·L KaplanP Elsbach
Apr 1, 1978·The Journal of Allergy and Clinical Immunology·R Patterson, K E Harris
Feb 1, 1978·Life Sciences·R PattersonP A Greenberger
Jan 1, 1974·Annual Review of Medicine·R Patterson, J F Kelly

Citations

Mar 1, 1991·Agents and Actions·P W StengelS A Silbaugh
Nov 1, 1992·Agents and Actions·S A SilbaughP W Stengel
Mar 3, 1994·European Journal of Pharmacology·P W StengelS A Silbaugh
Apr 1, 1987·Prostaglandins·P W StengelS A Silbaugh
Oct 1, 1998·European Journal of Pharmacology·P W StengelS A Silbaugh

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