Ionophore-based potentiometric sensors for the flow-injection determination of promethazine hydrochloride in pharmaceutical formulations and human urine.

Sensors
Ahmed Khudhair HassanSuad Mustafa Al-Araji

Abstract

Plasticised poly(vinyl chloride)-based membranes containing the ionophores (α-, β- and γ-cyclodextrins (CD), dibenzo-18-crown-6 (DB18C6) and dibenzo-30-crown-10 (DB30C10) were evaluated for their potentiometric response towards promethazine (PM) in a flow injection analysis (FIA) set-up. Good responses were obtained when β- and γ-CDs, and DB30C10 were used. The performance characteristics were further improved when tetrakis(4-chlorophenyl) borate (KTPB) was added to the membrane. The sensor based on β-CD, bis(2-ethylhexyl) adipate (BEHA) and KTPB exhibited the best performance among the eighteen sensor compositions that were tested. The response was linear from 1 × 10(-5) to 1 × 10(-2) M, slope was 61.3 mV decade(-1), the pH independent region ranged from 4.5 to 7.0, a limit of detection of 5.3 × 10(-6) M was possible and a lifetime of more than a month was observed when used in the FIA system. Other plasticisers such as dioctyl phenylphosphonate and tributyl phosphate do not show significant improvements in the quality of the sensors. The promising sensors were further tested for the effects of foreign ions (Li(+), Na(+), K(+), Mg(2+), Ca(2+), Co(2+), Cu(2+), Cr(3+), Fe(3+), glucose, fructose). FIA conditions (e.g., effects of...Continue Reading

References

Jan 1, 1992·Journal of Pharmaceutical and Biomedical Analysis·J Martinez Calatayud, T Garcia Sancho
Jun 20, 2001·Chemical & Pharmaceutical Bulletin·M U Adikwu, H D Höltje
May 16, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zuzana BosákováEva Tesarová
Dec 21, 2002·Carbohydrate Research·Thammarat Aree, Narongsak Chaichit
Dec 23, 2003·Journal of Professional Nursing : Official Journal of the American Association of Colleges of Nursing·Noreen Cavan Frisch
May 26, 2005·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Bahruddin SaadShariff Mahsufi
Apr 28, 2006·Trends in Analytical Chemistry : TRAC·Eric Bakker, Ernö Pretsch
Feb 27, 2007·Journal of Molecular Graphics & Modelling·Chunli YanCe Hao
Apr 26, 2007·Angewandte Chemie·Eric Bakker, Ernö Pretsch
Apr 27, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Einosuke TanakaKatsuya Honda
Jan 22, 2008·Journal of Pharmaceutical and Biomedical Analysis·Ana Rita PiresPetr Solich
Oct 7, 2008·Journal of Pharmaceutical and Biomedical Analysis·C G AmorimV L Silva
Dec 2, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·M Cruz-VeraM Valcárcel

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Gaussian03
HyperChem

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