PMID: 29485643Feb 28, 2018Paper

Ionoregulatory Disruption and Acetylcholinesterase Activity in Aluminium Toxicity: Effects of Vitamins C and E

Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria
R N UgbajaN O Aliyu-Banjo

Abstract

To investigate the effects of vitamin C and E on electrolyte profile and the activity of acetylcholinesterase (AChE) in Aluminium (Al) chloride exposed rats, thirty-six male rats were used for this study. The animals were randomly grouped into six (n=6); group I (Control) was given normal saline. Group II (Al only) was exposed to 20mg/kg body weight (BW) of Al. Groups III (Vitamin C only) and IV (Vitamin E only) were administered 200mg/kg BW of vitamin C and vitamin E respectively. Groups V (Al + Vit C) and VI (Al + Vit E) were exposed to 20mg/kg Al and were treated with 200mg/kg vitamin C and vitamin E respectively. Al exposure resulted in a significant (P<0.05) increase in plasma calcium and erythrocyte magnesium concentrations compared with control. The erythrocyte sodium concentration of group treated with Al alone was significantly (P<0.05) higher by 2.01folds than the control group. While the two vitamins were unable to correct the disruption in calcium homeostasis, they ameliorated the intracellular levels of sodium and magnesium ions. A reduction in the activity of AChE (1378.90±130.02U/L)was observed in erythrocyte of the group exposed to Al when compared to the control (1968.80±283.72U/L). Treatment with vitamins C an...Continue Reading

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