Ionotropic and metabotropic mechanisms in chemoreception: 'chance or design'?

EMBO Reports
Ana Florencia Silbering, Richard Benton

Abstract

Chemosensory receptors convert an enormous diversity of chemical signals from the external world into a common language of electrical activity in the brain. Mammals and insects use several families of transmembrane receptor proteins to recognize distinct classes of volatile and non-volatile chemicals that are produced by conspecifics or other environmental sources. A comparison of the signalling mechanisms of mammalian and insect receptors has revealed an unexpected functional distinction: mammals rely almost exclusively on metabotropic ligand-binding receptors, which use second messenger signalling cascades to indirectly activate ion channels, whereas insects use ionotropic receptors, which are gated directly by chemical stimuli, thereby leading to neuronal depolarization. In this review, we consider possible reasons for this dichotomy, taking into account biophysical, cell biological, ecological and evolutionary influences on how information is extracted from chemosensory cues by these animal classes.

References

Jan 1, 1987·Annals of the New York Academy of Sciences·K E KaisslingE R Rumbo
Jan 1, 1970·Die Naturwissenschaften·K E Kaissling, E Priesner
Jan 1, 1997·Annual Review of Neuroscience·J G Hildebrand, G M Shepherd
Aug 1, 1997·Biophysical Journal·S J Kleene
Oct 6, 1999·Current Opinion in Neurobiology·N J Strausfeld, J G Hildebrand
Jun 8, 2001·Neuron·M de BruyneJ R Carlson
Aug 18, 2001·Cell·G NelsonC S Zuker
Sep 15, 2001·Nature·R C Hardie, P Raghu
Mar 15, 2002·Nature·Greg NelsonCharles S Zuker
Jun 18, 2002·The Journal of Physiology·Hiroko Takeuchi, Takashi Kurahashi
Nov 5, 2002·Nature Reviews. Neuroscience·Gilles Laurent
May 29, 2003·Journal of Insect Physiology·Romina B. Barrozo, Karl Ernst Kaissling
Jul 8, 2003·Genome Biology·Hiroaki Matsunami, Hubert Amrein
Oct 21, 2003·Nature Neuroscience·Naoshige Uchida, Zachary F Mainen
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hugh M RobertsonJohn R Carlson
Nov 26, 2003·Cell·Grace Q ZhaoCharles S Zuker
Dec 20, 2003·Science·Rachel I WilsonGilles Laurent
Feb 24, 2004·Annual Review of Physiology·Mark L Mayer, Neali Armstrong
Jun 24, 2004·Cell·Elissa A HallemJohn R Carlson
Sep 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chris HagueKenneth P Minneman
Oct 1, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James J Moresco, Michael R Koelle
Jun 25, 2005·Science·Vikas BhandawatKing-Wai Yau
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·C Andrea YaoJohn R Carlson
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Yuko Ishida, Walter S Leal
Nov 5, 2005·Neuron·Barry W Ache, Janet M Young
Nov 5, 2005·Neuron·Kristin Scott
Jan 27, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hartwig SporsRainer W Friedrich
Feb 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Xavier GrosmaitreMinghong Ma
Jul 22, 2006·The Journal of Experimental Biology·Seth A Budick, Michael H Dickinson
Sep 30, 2006·Science·Russell D Fernald
Oct 31, 2006·Biochimica Et Biophysica Acta·Graeme Milligan
Nov 17, 2006·Nature·Jayaram ChandrashekarCharles S Zuker
Apr 10, 2007·Nature Neuroscience·Michelle L Schlief, Rachel I Wilson
May 3, 2007·The Journal of Biological Chemistry·Cristina F BushRandy A Hall
May 18, 2007·Annual Review of Neuroscience·Leslie B Vosshall, Reinhard F Stocker
Nov 17, 2007·FEBS Letters·Carolina LundinIngMarie Nilsson
Apr 15, 2008·Nature·Koji SatoKazushige Touhara
Jun 7, 2008·Journal of Chemical Ecology·M de Bruyne, T C Baker
Jun 27, 2008·Journal of Chemical Ecology·Ring T Cardé, Mark A Willis

❮ Previous
Next ❯

Citations

Mar 17, 2011·Nature Communications·H JanovjakE Y Isacoff
May 31, 2011·Chemical Senses·Maria Gabriela de Brito Sanchez
Mar 21, 2013·Chemical Senses·Mikael A CarlssonNiklas Janz
Jun 22, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Gabriela de Brito Sanchez, Martin Giurfa
Jul 12, 2013·Annual Review of Neuroscience·Rachel I Wilson
Mar 30, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elena StarostinaClaudio W Pikielny
Dec 20, 2011·Genetics and Molecular Research : GMR·J FanD F Cheng
Mar 12, 2011·Annual Review of Biochemistry·Julius Adler
Nov 17, 2015·Current Opinion in Insect Science·Ross M McKinneyYehuda Ben-Shahar
Sep 30, 2015·Insect Biochemistry and Molecular Biology·Colm CarraherAndrew V Kralicek
Mar 1, 2012·EMBO Reports·Simon Conway Morris
Sep 14, 2013·EMBO Reports·Carolina Gomez-Diaz, Richard Benton
Apr 5, 2014·The European Journal of Neuroscience·C Giovanni Galizia
Sep 29, 2015·Trends in Ecology & Evolution·Richard Benton
May 20, 2014·Journal of Physiology, Paris·F GuidobaldiP G Guerenstein
Mar 20, 2012·Current Opinion in Neurobiology·Jeffrey A Riffell
Dec 7, 2010·Progress in Neurobiology·Richard Glatz, Kelly Bailey-Hill
Nov 12, 2014·Proceedings of the National Academy of Sciences of the United States of America·Paul SzyszkaBrian H Smith
Nov 4, 2016·The Journal of Experimental Biology·Merid N GetahunBill S Hansson
Aug 31, 2017·Biological cybernetics·Irina SinakevitchBrian H Smith
Feb 6, 2020·Scientific Reports·Gabriela Caballero-VidalEmmanuelle Jacquin-Joly
Apr 21, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ashish Radadiya, John A Pickett
Dec 27, 2016·Frontiers in Cellular Neuroscience·Panagiota Tsitoura, Kostas Iatrou
Jan 4, 2019·Journal of Bioenergetics and Biomembranes·Eryn SlanksterDennis Mathew
Oct 24, 2020·ELife·Robert GreenhalghMerijn R Kant
Sep 9, 2015·Journal of Cell Science·Caitlin D Hanlon, Deborah J Andrew
Jun 16, 2021·Molecular Biology Reports·Danila V KolesovAlexey M Bogdanov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.