Ionotropic gelation: encapsulation of indomethacin in calcium alginate gel discs

Journal of Microencapsulation
V PillayN Hurbans

Abstract

Ionotropic gelation by divalent metal interaction was employed as an approach to design a modified release multiple-unit oral drug-delivery system. This process was achieved by crosslinking an indomethacin-sodium alginate dispersion with calcium ions to induce the spontaneous formation of indomethacin-calcium alginate gel discs. A significant part in the validation of the integrity of the system, involved a preformulatory stage for the optimization of the curing conditions and potency determination of the gel discs. A three-phase approach was developed to establish the critical curing parameters. Since curing involved crosslinking of the sodium alginate with calcium ions, an optimal concentration of calcium chloride (phase one) and crosslinking reaction-time (phase two) had to be determined. Furthermore, the third phase involved the optimization of the air-drying time of the gel discs. In phases one and two, stabilization of in vitro drug-release characteristics was used as the marker of optimal crosslinking efficiency. Phase three was based on achieving fully dried gel discs by drying to constant weight at 21 degrees C under an extractor. The study revealed that optimal crosslinking efficiency was achieved in 1%w/v calcium chl...Continue Reading

References

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Citations

Jul 16, 2005·Journal of Microencapsulation·Y Chen, X Lin
Oct 12, 2000·Drug Development and Industrial Pharmacy·T R BhardwajA Gupta
Aug 2, 2002·Drug Development and Industrial Pharmacy·Hanne Hjorth Tønnesen, Jan Karlsen
Jun 20, 2012·Carbohydrate Polymers·M A Abd El-GhaffarA M Rabie
Jul 5, 2005·International Journal of Pharmaceutics·D MukhopadhyayI G Tucker
Sep 13, 2006·Macromolecular Bioscience·Hossein OmidianKinam Park
Oct 22, 2019·Soft Matter·Katerina RementziDimitris Vlassopoulos
Apr 7, 2019·Bioprocess and Biosystems Engineering·Jessica Condi MainardiMichael Maas
May 28, 2003·Journal of Chemical Information and Computer Sciences·Suresh B SinghEugene M Fluder

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