PMID: 8592660Nov 1, 1995Paper

Iontophoresis enhances the transport of acyclovir through nude mouse skin by electrorepulsion and electroosmosis

Pharmaceutical Research
N M VolpatoP Colombo

Abstract

Iontophoresis was employed for enhancing the transdermal delivery of acyclovir through nude mouse skin in vitro, with the aim of understanding the mechanisms responsible for drug transport, in order to properly set the conditions of therapeutical application. Experiments were done in horizontal diffusion cells, using as donor a saturated solution of acyclovir at two different pH values (3.0 and 7.4). Different electrical conditions (current density and polarity) were employed. At pH 3.0, acyclovir anodal transport was due to electrorepulsion, since acyclovir was 20% in the protonated form. In acyclovir anodal iontophoresis at pH 7.4 the main mechanism involved was electroosmosis, since the drug was substantially unionized and the negative charge of the skin at this pH caused the electroosmotic flow to be from anode to cathode. In the case of cathodal iontophoresis at pH 3.0, acyclovir transport was enhanced approx. seven times, due to the presence of an electroosmotic contribution caused by the reversal of the charge of the skin. At pH 7.4 during cathodal iontophoresis acyclovir transport was not enhanced because the electroosmotic flow was in the opposite direction, compared to drug electric transport, i.e. anode to cathode. T...Continue Reading

Citations

Jul 20, 2006·Pharmaceutical Research·Nada AblaYogeshvar N Kalia
Sep 1, 2005·Pharmaceutical Research·Cristina PadulaPatrizia Santi
Jul 20, 2010·The Journal of Pharmacy and Pharmacology·Sara NicoliPatrizia Santi
Apr 8, 2021·Pharmaceutical Research·Kamchai SaepangDoungdaw Chantasart
Apr 10, 2004·International Journal of Pharmaceutics·Grazia StagniDaniella Weng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.