Iontophoretic delivery of calcium for experimental hydrofluoric acid burns

Critical Care Medicine
M YamashitaH Kajigaya

Abstract

To examine the efficacy of iontophoretic delivery of calcium to experimental hydrofluoric acid burns. Prospective, controlled study. Institutional laboratory. Male nude rats. For the in vitro experiment, a full-thickness skin from the back was set in a vertical flow-through diffusion cell. Calcium chloride was applied to the donor chamber, and transdermal transport of calcium was examined with or without a voltage gradient of 1.5 V. Either intact skin or skin whose stratum corneum was stripped with adhesive tapes was used. For the in vivo experiment, hydrofluoric acid burns were induced by dispensing 50% hydrofluoric acid (50 microL) on the backs of the nude rats, who were under pentobarbital anesthesia. Rats were divided into four groups (n = 5 for each group): control group (burned but not treated); topical group (treated with calcium gluconate jelly); infiltration group (intradermal and subcutaneous injection of calcium gluconate); and iontophoresis group (treated with iontophoresis of calcium chloride at 1.5 V). Burn areas were measured and pathologic findings were classified microscopically into five stages at 1 wk: stage 1, epidermal burn; stage 2, superficial dermal burn; stage 3, deep dermal burn; stage 4, full-thicknes...Continue Reading

References

Jun 1, 1989·Scandinavian Journal of Clinical and Laboratory Investigation·B GougetA Truchaud
Jul 1, 1988·Pharmaceutical Research·P GlikfeldR H Guy
Mar 1, 1988·The American Journal of Emergency Medicine·E M Caravati
Jan 1, 1986·The Journal of Burn Care & Rehabilitation·L S ZacharyM C Robson
Aug 1, 1986·Annals of Emergency Medicine·M V VanceS B Ruggeri
Aug 1, 1985·Burns, Including Thermal Injury·S P PeggG Gillett
Oct 1, 1974·British Journal of Industrial Medicine·S A CarneyC R Ricketts
Nov 30, 1970·JAMA : the Journal of the American Medical Association·M N LeemingW S Howland
Mar 1, 1966·American Journal of Clinical Pathology·H V Connerty, A R Briggs
Apr 1, 1983·Human Toxicology·J Velvart
May 1, 1995·The Journal of Burn Care & Rehabilitation·S T SeybM M Mani
Mar 1, 1997·The Clinical Journal of Pain·M A AshburnK Kessler
Jun 1, 1997·Pharmaceutical Research·J E Riviere, M C Heit

Citations

Jan 15, 2014·Burns : Journal of the International Society for Burn Injuries·Yuanhai ZhangChunmao Han
Jun 21, 2014·Burns : Journal of the International Society for Burn Injuries·Xingang WangChunmao Han
Apr 3, 2010·Dental Materials : Official Publication of the Academy of Dental Materials·B A C LoomansB Van Meerbeek
Oct 3, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·L TualG Dhonneur
May 18, 2004·Burns : Journal of the International Society for Burn Injuries·Martin W DünserPhilipp Lirk
Jun 9, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yiping WangBozena Michniak
Jan 28, 2014·International Journal of Occupational Medicine and Environmental Health·Yuanhai ZhangChunmao Han
May 5, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Felix JeremiasChristoph Janiak
Mar 3, 2005·The Annals of Pharmacotherapy·Elizabeth F KozyraLisa D Burry
Sep 5, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Tian ZhaoChristoph Janiak
Feb 19, 2004·The Annals of Pharmacotherapy·Lisa D Burry, Randy S Wax
Feb 3, 2005·Surgical Infections·Greg J Beilman
Jul 19, 2018·Pediatric Emergency Care·Gamze OzsoyHuseyin Dindar
Apr 12, 2013·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ni ZhangJunting Wang
Mar 1, 2019·Scientific Reports·Mohaddeseh VafaieePezhman Sasanpour

Related Concepts

Administration, Topical
Metazoa
Chemical Burns
Calcium Chloride, Anhydrous
Glucobiogen
Gel
Hydrofluoric Acid
Iontophoresis
Rats, Laboratory

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