Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin

International Journal of Pharmaceutics
Ponwanit CharoenputtakunTanansait Ngawhirunpat

Abstract

The combined effects of iontophoresis and lipid nanoparticles on drug delivery across human epidermal membrane (HEM) were investigated. The delivery of lipophilic and hydrophilic drugs, all trans-retinoic acid (ATRA), salicylate (SA), and acyclovir (ACV), across HEM from lipid nanoparticles, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), was compared in passive and iontophoresis experiments in vitro. Iontophoresis experiments were also performed with synthetic Nuclepore membrane for comparison. Drug distribution in the skin after iontophoretic delivery with the lipid nanoparticles was examined using a model probe rhodamine B base (RhoB). The drug-loaded lipid nanoparticles had average sizes of ∼ 118-169 nm and a negative zeta potential. Iontophoresis did not enhance the delivery of ATRA across HEM from SLN and NLC. However, HEM distribution study of RhoB suggested that lipophilic drugs could be delivered into the deeper layer of the skin following iontophoretic delivery of the drugs from the lipid nanoparticles. Iontophoresis enhanced the delivery of hydrophilic drug SA with the lipid nanoparticles. Similarly, iontophoresis enhanced the delivery of ACV when it was loaded in SLN. These results suggest t...Continue Reading

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Citations

Mar 11, 2016·Colloids and Surfaces. B, Biointerfaces·Hoang Truc Phuong NguyenEmilie Munnier
Oct 6, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A-S BoisgardB Verrier
Oct 21, 2016·AAPS PharmSciTech·Vanessa F CarvalhoLuciana B Lopes
Mar 14, 2017·Expert Opinion on Drug Delivery·Hyeongmin KimJaehwi Lee
Apr 30, 2016·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Jessica OtarolaPatricia G Molina
Jul 31, 2020·Pharmaceuticals·Pratheeksha Koppa RaghuNeelesh Kumar Mehra
Apr 8, 2021·Pharmaceutical Research·Kamchai SaepangDoungdaw Chantasart

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