Iontophoretic transepithelial corneal cross-linking to halt keratoconus in pediatric cases: 15-month follow-up

Cornea
Luca BuzzonettiSergio Petroni

Abstract

To report the results 15 months after transepithelial corneal cross-linking by iontophoresis of riboflavin performed in pediatric patients affected by keratoconus. Fourteen eyes of 14 pediatric patients [mean age 13 ± 2.4 (SD) years; range, 10-18 years] were treated. Riboflavin solution was administered by iontophoresis for 5 minutes, and then UVA irradiation (10 mW/cm) was performed for 9 minutes. The corrected distance visual acuity measured as decimal number, spherical equivalent, refractive astigmatism, simulated K, corneal coma, spherical aberration, and high-order aberrations for 5.0-mm pupil and the thinnest point were measured preoperatively and 3, 6, 12, and 15 months postoperatively. The endothelial cell density was evaluated. The paired Student t test was used to compare data during the follow-up. Fifteen months after the procedure, the corrected distance visual acuity improved from 0.7 ± 1.7 to 0.8 ± 1.8 (P = 0.005). Spherical equivalent and refractive astigmatism as well as topographic and aberrometric data did not show significant changes. Also, the mean thinnest point and the endothelial cell density remained unchanged. The optical coherence tomography showed a nonhomogeneous but deep hyperreflective band with a ...Continue Reading

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Citations

Jun 4, 2016·Journal of Cataract and Refractive Surgery·Shihao ChenQinmei Wang
Mar 31, 2016·Cornea·Daniel A GodefrooijRobert P L Wisse
Jun 17, 2016·Expert Opinion on Drug Delivery·Maxime LafondCyril Lafon
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