Iontophoretic transport across a synthetic membrane and human epidermal membrane: a study of the effects of permeant charge

Journal of Pharmaceutical Sciences
S Kevin LiWilliam I Higuchi

Abstract

The effects of permeant charge (z) on iontophoretic-enhanced transport were investigated with synthetic Nucleopore membranes and with human epidermal membranes using a four-electrode potentiostat with side-by-side diffusion cells. The modified Nernst-Planck model (Nernst-Planck theory with an additional transport term to correct for the effect of the convective solvent flow due to electroosmosis) was first examined in a Nuclepore membrane system with model permeants calcein (z = -4), salicylate (z = -1), and a series of polystyrene sulfonates (from monomer to molecular weight of approximately 8000 with a z range of -1 to approximately -40). The flux enhancement (E) for each permeant was determined at 470 mV. Mannitol (a neutral molecule) was used as a probe to determine a correction for convective solvent flow under the same applied voltage conditions. Good agreement between the experimental results and the predictions from the modified Nernst-Planck model was found for calcein, salicylate, and polystyrene sulfonates up to molecular weight of approximately 1800 (z approximately -8). The flux enhancements for the higher molecular weight polystyrene sulfonates with greater z values were more than a factor of three lower than theo...Continue Reading

References

Feb 1, 1990·Pharmaceutical Research·G B Kasting, L A Bowman
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R PrausnitzJ C Weaver

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Citations

Jul 15, 2006·Pharmaceutical Research·S Kevin LiWilliam I Higuchi
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Honggang ZhuWilliam I Higuchi
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Kevin LiMatthew S Hastings
Jun 24, 2003·International Journal of Pharmaceutics·Sandip B Tiwari, N Udupa
Mar 4, 1999·International Journal of Pharmaceutics·A K BangaT K Ghosh
May 12, 2012·Advanced Drug Delivery Reviews·Yuri G AnissimovMichael S Roberts
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·W I HiguchiY Song
Jan 25, 2011·Journal of Pharmaceutical Sciences·Mark R LiddellWilliam I Higuchi
Apr 5, 2008·Journal of Pharmaceutical Sciences·Jinsong Hao, S Kevin Li
Mar 1, 2005·Journal of Pharmaceutical Sciences·S Kevin LiHenry S White
Nov 12, 2009·Journal of Pharmaceutical Sciences·Kelly A SmithS Kevin Li
Nov 26, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Wei RenS Kevin Li
Jan 29, 2011·Journal of Pharmaceutical and Biomedical Analysis·S Kevin LiHe Wen
Jul 13, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Charu Kochhar, Georgios Imanidis
Oct 9, 1999·Journal of Pharmaceutical Sciences·S K LiW I Higuchi

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