Iontophoretic transport pathways: dependence on penetrant physicochemical properties

Journal of Pharmaceutical Sciences
N G Turner, Richard H Guy

Abstract

The objective of this work was to investigate how the preferred iontophoretic transport pathways of a molecule depend on its physicochemical properties. Laser scanning confocal microscopy (LSCM) was used to visualize in hairless mouse skin the distribution of two fluorescent penetrants: calcein, a multiply charged (-4), hydrophilic molecule; and nile red, a lipophilic, neutral compound. Iontophoresis and passive delivery of nile red showed that the percutaneous transport of this compound occurred via (inter- and intracellular) pathways that were clearly distinct from those followed by calcein. Although the distribution of nile red was influenced somewhat by the passage of current relative to the passive control, there was relatively little enhancement of the penetration of this compound into the skin. Calcein, on the other hand, did not passively enter the skin. However, with iontophoresis, greatly enhanced transport, with an important contribution from follicular structures, was observed. Sequential (dual) transport of the two fluorophores illustrated clearly the different pathways followed and reflected the transport and visualization studies of the individual species. It may be concluded, therefore, that the iontophoretic pa...Continue Reading

References

Jul 1, 1988·Pharmaceutical Research·P GlikfeldR H Guy
Mar 1, 1985·The Journal of Cell Biology·P GreenspanS D Fowler
Mar 15, 1982·Toxicology and Applied Pharmacology·R L BronaughE R Congdon
Jul 1, 1952·The Journal of Investigative Dermatology·W MONTAGNAH P MELARAGNO

❮ Previous
Next ❯

Citations

Aug 4, 2005·Pharmaceutical Research·Ayyappa ChaturvedulaAjay K Banga
Feb 10, 2006·Pharmaceutical Research·Yasuko ObataKozo Takayama
Dec 7, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Carola BrusThomas Kissel
Oct 21, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·B A van den BerghP W Wertz
Sep 28, 1999·Magnetic Resonance Imaging·J B CabanB R Locke
Sep 21, 2000·Pharmaceutical Science & Technology Today·A NaikR H Guy
Jul 9, 2005·Journal of Biomaterials Science. Polymer Edition·Xueqin ZhouYaqin Fang
Jan 1, 2008·Indian Journal of Pharmaceutical Sciences·Swati RawatG Srikarti
Dec 14, 2011·Expert Opinion on Drug Delivery·Maria Begoña Delgado-Charro
Jun 13, 2016·Computers in Biology and Medicine·N C F MachadoP P Favero
Dec 18, 2013·Advanced Drug Delivery Reviews·M Begoña Delgado-Charro, Richard H Guy
Apr 8, 2017·Journal of Clinical Pharmacology·Florence Gaillard-BigotJean-Luc Cracowski
Aug 5, 2017·Chemistry, an Asian Journal·Juan TangJun-Long Zhang
Nov 1, 2002·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Narayanasamy Kanikkannan
Jul 20, 2010·The Journal of Pharmacy and Pharmacology·Oliver W AckaertJoke A Bouwstra
Apr 8, 2021·Pharmaceutical Research·Kamchai SaepangDoungdaw Chantasart
Aug 2, 2008·Analytical Chemistry·Joselito P Quirino, Paul R Haddad
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·R Alvarez-RománR H Guy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.