IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways

European Journal of Pharmacology
Norhafiza RazaliNafeeza M Ismail

Abstract

Trans-resveratrol was earlier shown to lower intraocular pressure (IOP) in rats; however, its mechanisms of action remain unclear. It has been shown to modulate adenosine receptor (AR) and TGF-β2 signaling, both of which play a role in regulating IOP. Hence, we investigated effects of trans-resveratrol on AR and TGF-β2 signaling. Steroid-induced ocular hypertensive (SIOH) rats were pretreated with A1AR, phospholipase C (PLC) and ERK1/2 inhibitors and were subsequently treated with single drop of trans-resveratrol. Metalloproteinases (MMP)-2 and -9 were measured in aqueous humor (AH). In another set of experiments, effect of trans-resveratrol on AH level of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) was determined after single and multiple drop administration in SIOH rats. Effect of trans-resveratrol on ARs expression, PLC and pERK1/2 activation and MMPs, tPA and uPA secretion was determined using human trabecular meshwork cells (HTMC). Further, effect of trans-resveratrol on TGF-β2 receptors, SMAD signaling molecules and uPA and tPA expression by HTMC was determined in the presence and absence of TGF-β2. Pretreatment with A1AR, PLC and ERK1/2 inhibitors antagonized the IOP lowering effect of tr...Continue Reading

Citations

Dec 25, 2019·Metallomics : Integrated Biometal Science·Yifei HeYonggui He
Jul 23, 2020·Journal of Basic and Clinical Physiology and Pharmacology·Normie Aida Mohd NasirIgor Iezhitsa
Apr 11, 2019·Current Pharmaceutical Design·Tanzir RafeMd Abu Taher Sagor
Jun 6, 2019·Nutrients·Patricia Alonso-AndrésJosé Luis Albasanz
Aug 21, 2019·Cells·Maurizio CammalleriPaola Bagnoli
Jul 11, 2021·Life Sciences·Shahin HallajFarhad Jadidi-Niaragh
Aug 31, 2021·Journal of Agricultural and Food Chemistry·Yen-Chun KohMin-Hsiung Pan

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