Iopanoic acid rapidly controls type I amiodarone-induced thyrotoxicosis prior to thyroidectomy

Journal of Endocrinological Investigation
F BogazziEnio Martino

Abstract

Amiodarone-induced thyrotoxicosis (AIT) may develop either in apparently normal thyroid glands (Type II AIT) or in the presence of sub-clinical thyroid abnormalities (either autonomous goiter or latent Graves' disease; Type I AIT). Mixed forms also occur. While Type I AIT is due to iodine-induced excess thyroid hormone synthesis, Type II AIT is a form of amiodarone (possibly iodine) -induced destructive thyroiditis. Type I AIT is usually treated by combined thionamide and potassium perchlorate therapy, but may be resistant to therapy. On the other hand, Type II AIT often responds favorably to glucocorticoids and may not require further therapy once euthyroidism has been restored. Not infrequently, however, AIT (especially Type I) is resistant to conventional treatment, and several weeks or months may elapse before euthyroidism is restored. Thyroidectomy has been carried out in Type I AIT patients, but thyroid surgery in thyrotoxic patients, especially those with underlying cardiac problems, carries a high surgical risk. In this study we describe 3 patients with Type I AIT, who were successfully treated with a short course of iopanoic acid (IOP), an oral cholecystographic agent, which is rich in iodine and is a potent inhibitor ...Continue Reading

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Citations

Feb 19, 2002·Clinical Endocrinology·Luigi BartalenaEnio Martino
Sep 21, 2006·Clinical Endocrinology·Leandro Arthur DiehlWilmar M Wiersinga
Jul 2, 2005·The American Journal of Medicine·Shehzad Basaria, David S Cooper
Nov 15, 2007·Journal of Medical Case Reports·Vasilios PapaioannouIoannis Pneumatikos
Aug 17, 2011·Journal of Thyroid Research·Taimur SaleemQamar Masood
Jun 1, 2011·Therapeutic Advances in Endocrinology and Metabolism·Shashithej K NarayanaChristopher J Boos
Apr 8, 2004·Thyroid : Official Journal of the American Thyroid Association·Laura E RyanRichard T Kloos
Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Nov 13, 2003·Thyroid : Official Journal of the American Thyroid Association·Gerhard H ScholzRalf Paschke
Apr 18, 2003·Thyroid : Official Journal of the American Thyroid Association·Murat Faik ErdoganGürbüz Erdogan
Jun 15, 2005·Expert Opinion on Pharmacotherapy·Luigi BartalenaEnio Martino
Aug 8, 2014·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nicole M TyerDorothy S Martinez
Sep 24, 2019·The Journal of Clinical Endocrinology and Metabolism·Daniele CappellaniFausto Bogazzi
May 3, 2003·The Journal of Clinical Endocrinology and Metabolism·Fausto BogazziEnio Martino
Jul 18, 2020·The Journal of Clinical Endocrinology and Metabolism·Daniele CappellaniFausto Bogazzi
Jun 27, 2003·The New England Journal of Medicine·Elizabeth N PearceLewis E Braverman
May 26, 2018·Journal of Investigative Medicine High Impact Case Reports·Dimpi DesaiVafa Tabatabaie
Aug 7, 2010·Southern Medical Journal·Hema Padmanabhan

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