IP-10 Kinetics in the First Week of Therapy are Strongly Associated with Bacteriological Confirmation of Tuberculosis Diagnosis in HIV-Infected Patients

Scientific Reports
Alberto L García-BasteiroRichard M Anthony

Abstract

Simple effective tools to monitor the long treatment of tuberculosis (TB) are lacking. Easily measured host derived biomarkers have been identified but need to be validated in larger studies and different population groups. Here we investigate the early response in IP-10 levels (between day 0 and day 7 of TB therapy) to identify bacteriological status at diagnosis among 127 HIV-infected patients starting TB treatment. All participants were then classified as responding or not responding to treatment blindly using a previously described IP-10 kinetic algorithm. There were 77 bacteriologically confirmed cases and 41 Xpert MTB/RIF® and culture negative cases. Most participants had a measurable decline in IP-10 during the first 7 days of therapy. Bacteriologically confirmed cases were more likely to have high IP-10 levels at D0 and had a steeper decline than clinically diagnosed cases (mean decline difference 2231 pg/dl, 95% CI: 897-3566, p = 0.0013). Bacteriologically confirmed cases were more likely to have a measurable decline in IP-10 at day 7 than clinically diagnosed cases (48/77 (62.3%) vs 13/41 (31.7%), p < 0.001). This study confirms the association between a decrease in IP-10 levels during the first week of treatment and ...Continue Reading

References

Jul 1, 1995·The Journal of Experimental Medicine·A L AngiolilloG Tosato
Mar 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jennifer H DufourAndrew D Luster
May 3, 2003·The Lancet Infectious Diseases·Kamran SiddiqiJohn Walley
Mar 28, 2013·Mediators of Inflammation·Giulio KleinerGiorgio Zauli
Jun 8, 2013·The Lancet Infectious Diseases·Dennis FalzonMario C Raviglione
Oct 26, 2013·International Journal of Epidemiology·Charfudin SacoorTacilta Nhampossa
Dec 7, 2013·The European Respiratory Journal·Novel N ChegouMorten Ruhwald
Mar 24, 2015·Tuberculosis·Vanessa CliffordNigel Curtis
Nov 20, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yunan ZhuHongyan Diao
Dec 25, 2015·The European Respiratory Journal·Elisa López-VarelaAlberto L García-Basteiro
Apr 1, 2016·Expert Review of Respiratory Medicine·Neesha RockwoodRobert J Wilkinson
Oct 26, 2016·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·L PetroneD Goletti
Oct 27, 2016·BMC Infectious Diseases·Alberto L García-BasteiroPedro L Alonso
Mar 13, 2017·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·S ValenciaA L García-Basteiro
Mar 24, 2017·The European Respiratory Journal·Alberto L García-BasteiroEusebio Macete

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Methods Mentioned

BETA
X-Ray
ELISA
light smear microscopy

Software Mentioned

STATA
R

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