IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection

Scientific Reports
K TonbyAnne Ma Dyrhol-Riise

Abstract

Tuberculosis (TB) has huge impact on human morbidity and mortality and biomarkers to support rapid TB diagnosis and ensure treatment initiation and cure are needed, especially in regions with high prevalence of multi-drug resistant TB. Soluble interferon gamma inducible protein 10 (IP-10) analyzed from dry plasma spots (DPS) has potential as an immunodiagnostic marker in TB infection. We analyzed IP-10 levels in plasma directly and extracted from DPS in parallel by ELISA from 34 clinically well characterized patients with TB disease before and throughout 24 weeks of effective anti-TB chemotherapy. We detected a significant decline of IP-10 levels in both plasma and DPS already after two weeks of therapy with good correlation between the tests. This was observed both in pulmonary and extrapulmonary TB. In conclusion, plasma IP-10 may serve as an early biomarker for anti-TB chemotherapy responses and the IP-10 DPS method has potential to be developed into a point-of care test for use in resource-limited settings. Further studies must be performed to validate the use of IP-10 DPS in TB high endemic countries.

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Citations

Mar 8, 2016·Expert Opinion on Drug Metabolism & Toxicology·Marlanka A ZuurJan-Willem C Alffenaar
Aug 15, 2015·The Journal of Infection·Vanessa CliffordNigel Curtis
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Dec 31, 2019·Journal of Immunology Research·Eleane de OyarzabalMartha Torres
Jul 29, 2017·Frontiers in Cellular and Infection Microbiology·Soomin ParkIn-Hong Choi
Oct 29, 2017·Scientific Reports·Julián CandiaAngélique Biancotto
Jul 22, 2018·Frontiers in Immunology·Thomas BlauenfeldtMorten Ruhwald
Apr 30, 2019·Expert Review of Proteomics·Deepa BishtVivek Kumar Gupta
Mar 22, 2018·Frontiers in Veterinary Science·Ting XinHong Jia
Oct 6, 2020·Frontiers in Immunology·Claudia CarranzaMartha Torres
Mar 19, 2021·Frontiers in Immunology·Bih H ChendiAnne M Dyrhol-Riise
Jun 26, 2021·Frontiers in Immunology·Sonya KrishnanPetros C Karakousis
Jul 1, 2021·Clinical & Translational Immunology·Jessica L PedersenBernadette M Saunders
Jun 19, 2021·Tuberculosis·Shunsuke UnoNaoki Hasegawa
Jul 27, 2021·Frontiers in Cellular and Infection Microbiology·Marthe Jøntvedt JørgensenAnne Ma Dyrhol-Riise

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Methods Mentioned

BETA
ELISA
X-ray
ESR
biopsies

Software Mentioned

SPSS
Prism
GraphPad

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