IP-receptor and PPARs trigger the conversion of human white to brite adipocyte induced by carbaprostacyclin

Biochimica Et Biophysica Acta
Rayane A GhandourDidier F Pisani

Abstract

Brite adipocytes recently discovered in humans are of considerable importance in energy expenditure by converting energy excess into heat. This property could be useful in the treatment of obesity, and nutritional aspects are relevant to this important issue. Using hMADS cells as a human cell model which undergoes a white to a brite adipocyte conversion, we had shown previously that arachidonic acid, the major metabolite of the essential nutrient Ω6-linoleic acid, plays a major role in this process. Its metabolites PGE2 and PGF2 alpha inhibit this process via a calcium-dependent pathway, whereas in contrast carbaprostacyclin (cPGI2), a stable analog of prostacyclin, activates white to brite adipocyte conversion. Herein, we show that cPGI2 generates via its cognate cell-surface receptor IP-R, a cyclic AMP-signaling pathway involving PKA activity which in turn induces the expression of UCP1. In addition, cPGI2 activates the pathway of nuclear receptors of the PPAR family, i.e. PPARα and PPARγ, which act separately from IP-R to up-regulate the expression of key genes involved in the function of brite adipocytes. Thus dual pathways are playing in concert for the occurrence of a browning process of human white adipocytes. These resu...Continue Reading

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Citations

Jul 8, 2016·Adipocyte·Claude ForestPhilippe Noirez
Jan 19, 2018·Journal of Lipid Research·Rayane A GhandourDidier F Pisani
Sep 8, 2018·Journal of Cellular Physiology·Hanél Sadie-Van Gijsen
Nov 16, 2018·Journal of Cellular Physiology·Mohammad Sharifur Rahman
Jul 6, 2018·EMBO Molecular Medicine·Irem Bayindir-BuchhalterAlexandros Vegiopoulos
Jul 11, 2020·The Biochemical Journal·Yasuhiro OnogiSiegfried Ussar
Jun 30, 2019·International Journal of Molecular Sciences·Pei-Chi ChanPo-Shiuan Hsieh
Mar 11, 2020·Frontiers in Endocrinology·Sebastian DieckmannMartin Klingenspor
Apr 26, 2018·Science Signaling·Rohollah BabaeiAlexandros Vegiopoulos
Jan 17, 2021·International Journal of Molecular Sciences·Piotr WójcikElżbieta Skrzydlewska
Aug 8, 2021·International Journal of Molecular Sciences·Egor A TurovskyMaria V Turovskaya

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