IPF: new insight on pathogenesis and treatment

Allergy
S Harari, A Caminati

Abstract

Recent years have seen a robust influx of exciting new observations regarding the mechanisms that regulate the initiation and progression of pulmonary fibrosis but the pathogenesis remains poorly understood. The search for an alternative hypothesis to unremitting, chronic inflammation as the primary explanation for the pathophysiology of idiopathic pulmonary fibrosis (IPF) derives, in part, from the lack of therapeutic efficacy of high-dose immunosuppressive therapy in patients with IPF. The inflammatory hypothesis of IPF has since been challenged by the epithelial injury hypothesis, in which fibrosis is believed to result from epithelial injury, activation, and/or apoptosis with abnormal wound healing. This hypothesis suggests that recurrent unknown injury to distal pulmonary parenchyma causes repeated epithelial injury and apoptosis. The resultant loss of alveolar epithelium exposes the underlying basement membrane to oxidative damage and degradation. Emerging concepts suggest that IPF is the result of epithelial-mesenchymal interaction. The initiation of this fibrotic response may depend upon genetic factors and environmental triggers; the role of Th1 or Th2 cell-derived cytokines may also be important. This process appears ...Continue Reading

References

Aug 1, 1991·American Journal of Respiratory Cell and Molecular Biology·N KhalilA H Greenberg
Oct 1, 1990·The Journal of Clinical Investigation·H N AntoniadesM Selman
Feb 1, 1989·The American Review of Respiratory Disease·A M CantinR G Crystal
Jun 1, 1987·The Journal of Clinical Investigation·A M CantinR G Crystal
Oct 1, 1985·The Journal of Pathology·B CorrinM Turner-Warwick
Jan 1, 1983·Respiration; International Review of Thoracic Diseases·E WeitzenblumC Hirth
Oct 1, 1994·American Journal of Respiratory and Critical Care Medicine·D B CoultasR E Sobonya
Nov 10, 1994·The New England Journal of Medicine·W A Border, N A Noble
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·D A SchwartzG W Hunninghake
Mar 28, 1998·The Journal of Experimental Medicine·D XuF Y Liew
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·S E GayF J Martinez
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Jul 1, 1996·Nature Biotechnology·S E HoltW E Wright
Aug 11, 1998·Nature Genetics·A Di CristofanoP P Pandolfi
Jul 7, 1999·The Journal of Clinical Investigation·K KuwanoN Hara
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H Y Zhang, S H Phan
Mar 8, 2000·Mechanisms of Development·D WarburtonW V Cardoso
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·K AoshibaA Nagai
Sep 16, 2000·American Journal of Respiratory and Critical Care Medicine·D A VassilakisD Bouros
Nov 9, 2000·American Journal of Respiratory and Critical Care Medicine·M SugaM Ando
Nov 15, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·V J Thannickal, B L Fanburg
Jan 12, 2001·American Journal of Respiratory Cell and Molecular Biology·Y MorishimaK Sekizawa
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
Mar 7, 2001·The Journal of Investigative Dermatology·X Shi-WenD J Abraham
Jul 21, 2001·American Journal of Respiratory and Critical Care Medicine·A L Katzenstein, J L Myers
Aug 25, 2001·The New England Journal of Medicine·T J Gross, G W Hunninghake
Oct 6, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Oct 24, 2001·American Journal of Respiratory and Critical Care Medicine·T E KingR M Cherniack
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·A G Nicholson, A U Wells
Nov 24, 2001·American Journal of Respiratory and Critical Care Medicine·K R FlahertyF J Martinez
Mar 7, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael PappBruce D Uhal
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Frieder Schock, Norbert Perrimon
Oct 16, 2002·Laboratory Investigation; a Journal of Technical Methods and Pathology·Marco ChilosiClaudio Doglioni
Dec 12, 2002·Chest·Sem H Phan

❮ Previous
Next ❯

Citations

Sep 3, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Hilal ErmisZeynep Ayfer Aytemur
Jul 13, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marco PrunottoSolange Moll
Aug 13, 2011·Current Opinion in Pulmonary Medicine·Marios A Mouratis, Vassilis Aidinis
Jan 1, 2011·BMJ Case Reports·Raphael Chinedu AnakwueNneka Ifeyinwa Iloanusi
Apr 7, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lynn M Crosby, Christopher M Waters
Oct 22, 2011·American Journal of Respiratory and Critical Care Medicine·Thomas J RichardsKevin F Gibson
May 15, 2012·American Journal of Respiratory and Critical Care Medicine·Rosa FanerAlvar Agustí
Feb 9, 2012·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xian-mei ZhouJian-xin Li
Oct 7, 2010·Expert Review of Respiratory Medicine·Aaron GardnerAndrew J Fisher
Nov 26, 2013·The Veterinary Clinics of North America. Small Animal Practice·Henna P Heikkilä-Laurila, Minna M Rajamäki
Jan 26, 2013·Drug Discovery Today·Solange MollMarco Prunotto
Mar 10, 2011·Mathematical Biosciences·Bryan N BrownYoram Vodovotz
Aug 17, 2010·Pulmonary Pharmacology & Therapeutics·Bernt van den BlinkHenk C Hoogsteden
Jun 16, 2012·The Clinical Respiratory Journal·Ole HilbergElisabeth Bendstrup
Oct 28, 2011·Clinical and Translational Science·Daniel J Kass, Naftali Kaminski
Jul 23, 2015·Mediators of Inflammation·Michelle A Murray, Sanjay H Chotirmall
Oct 5, 2010·Respiratory Medicine·Nicoline M KorthagenJan C Grutters
Aug 1, 2015·PloS One·Alejandro Guzmán-SilvaRoberto Berra-Romani
Jun 10, 2016·General Thoracic and Cardiovascular Surgery·Satoru KobayashiMasayuki Chida
Sep 25, 2016·European Journal of Radiology·Delphine L ChenEdwin J R van Beek
Jan 21, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wupeng LiaoWai-Shiu Fred Wong
Dec 12, 2017·F1000Research·Chiara ScelfoSergio Harari
Oct 19, 2010·Therapeutic Advances in Respiratory Disease·William R CowardGisli Jenkins
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Gianluca Bagnato, Sergio Harari
Jun 20, 2019·The Journal of Pharmacy and Pharmacology·Ayse Karatug KacarFusun Oztay
Jun 1, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Shanna L AshleyBethany B Moore
Feb 6, 2017·Medical Mycology·Bruna PippiAlexandre Meneghello Fuentefria
Oct 14, 2017·Bioscience Reports·Michael Kasper, Kathrin Barth
Feb 3, 2018·International Journal of Molecular Medicine·Ju KuangXiaolin Wei
Sep 19, 2018·International Journal of Molecular Sciences·Luis G Vazquez-de-LaraRoberto Berra-Romani
Jul 22, 2020·American Journal of Respiratory Cell and Molecular Biology·Manisha AgarwalKevin K Kim
Jul 20, 2021·Therapeutic Advances in Respiratory Disease·Timothy N Perkins, Tim D Oury
Jul 19, 2021·Experimental Gerontology·Gurparsad Singh SuriManish Tiwari

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