iPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.

PloS One
Lindsay CalderonMing C Gong

Abstract

Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown. The current study addresses this question by evaluating the basal- and angiotensin II infusion-induced vascular remodeling and hypertension in smooth muscle specific iPLA(2)β transgenic (iPLA(2)β-Tg) mice. Blood pressure was monitored by radiotelemetry and vascular remodeling was assessed by morphologic analysis. We found that the angiotensin II-induced increase in diastolic pressure was significantly higher in iPLA(2)β-Tg than iPLA(2)β-Wt mice, whereas, the basal blood pressure was not significantly different. The media thickness and media∶lumen ratio of the mesenteric arteries were significantly increased in angiotensin II-infused iPLA(2)β-Tg mice. Analysis revealed no difference in vascular smooth muscle cell proliferation. In contrast, adenovirus-mediated iPLA(2)β overexpression in cultured vascular smooth muscle cells promoted angiotensin II-induced [(3)H]-leucine incorporation, indicating enhanced hypertrophy. Moreover, angiotensin II infusion-induced c-Jun phosphorylation in vascular smooth muscle cell...Continue Reading

References

Feb 12, 1998·The American Journal of Physiology·E J FreemanR V Dorman
Jun 5, 2002·The Journal of Clinical Investigation·Fumito IchinoseWarren M Zapol
Jul 3, 2002·The Journal of Clinical Investigation·Zhonghua QiMatthew D Breyer
Jun 7, 2003·Advances in Enzyme Regulation·John H EvansChristina C Leslie
Jan 20, 2004·Nature Cell Biology·Tarik SmaniVictoria M Bolotina
Sep 17, 2004·The Journal of Clinical Investigation·Takayuki FujinoFumitaka Ushikubi
Jan 8, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Fang Li, Kafait U Malik
May 4, 2005·Hypertension·Carmel M McEnieryUNKNOWN ENIGMA Study Investigators
Jan 13, 2006·Circulation·Thomas ThomUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Oct 13, 2006·American Journal of Human Genetics·Shareef KhateebOhad S Birk
Dec 25, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Kristen M ParkVictoria M Bolotina
Oct 28, 2008·American Journal of Physiology. Heart and Circulatory Physiology·François-Xavier BoittinJean-Louis Bény
Dec 17, 2008·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Jan 28, 2009·Circulation·Donald Lloyd-JonesUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Apr 13, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Hans H DietrichRichard W Gross
Jun 10, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hui LiYan Xu
Dec 28, 2010·Progress in Lipid Research·Makoto MurakamiKei Yamamoto
Feb 26, 2011·Arteriosclerosis, Thrombosis, and Vascular Biology·Kohei TanakaIchiro Hisatome

❮ Previous
Next ❯

Citations

Jan 9, 2013·Expert Opinion on Therapeutic Patents·Victoria Magrioti, George Kokotos
Oct 27, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Jie SuGui-Yuan Lv
Jun 7, 2018·Physiological Reviews·Steven J ForresterSatoru Eguchi
Dec 8, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Janice M Diaz-OteroAnne M Dorrance

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
electrophoresis
scintillation spectroscopy

Software Mentioned

Olympus
GraphPad Prism
MicroSuit -
Dataquest

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.