Ipragliflozin Ameliorates Liver Damage in Non-alcoholic Fatty Liver Disease

Open Medicine
Teruki MiyakeYoichi Hiasa

Abstract

There are few effective medications for non-alcoholic steatohepatitis (NASH). We investigated the efficacy of ipragliflozin (selective sodium-glucose cotransporter-2 inhibitor [SGLT2I]) for the treatment of patients with type 2 diabetes mellitus (T2DM) complicated by non-alcoholic fatty liver disease (NAFLD). We prospectively enrolled patients with T2DM complicated by NAFLD treated at our institutions from January 2015 to December 2016. Patients received oral ipragliflozin (50 mg/day) once daily for 24 weeks. Body composition was evaluated using an InBody720 analyzer. We used transient elastography to measure liver stiffness and the controlled attenuation parameter for the quantification of liver steatosis in patients with NASH. Forty-three patients with T2DM and NAFLD were enrolled (12 with biopsy-proven NASH and 31 with NAFLD diagnosed by ultrasonography). After 24 weeks, body weight, hemoglobin A1c (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase, body fat mass, and steatosis were significantly decreased compared to baseline measurements in patients with NASH. However, muscle mass was not reduced, and liver stiffness showed a statistically insignificant tendency to decr...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Sep 14, 1999·The American Journal of Gastroenterology·E M BruntB R Bacon
Jul 27, 2001·Diabetes·G MarchesiniN Melchionda
Jun 22, 2002·Journal of Hepatology·Masahiko ShimadaJurgen Ludwig
Oct 31, 2002·Gastroenterology·Arun J Sanyal, UNKNOWN American Gastroenterological Association
Apr 2, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Giulio MarchesiniMario Rizzetto
Nov 14, 2003·Journal of Gastroenterology·Sei-Ichiro KojimaShohei Matsuzaki
Dec 31, 2003·Ultrasound in Medicine & Biology·Laurent SandrinRobert Palau
Dec 29, 2004·Journal of Gastroenterology·Yoko YoshiokaKeiko Shiratori
Sep 11, 2007·Journal of Atherosclerosis and Thrombosis·Tamio TeramotoUNKNOWN Japan Atherosclerosis Society (JAS) Committee for Epidemiology and Clinical Management of Atherosclerosis
Dec 4, 2008·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Nila RafiqZobair M Younossi
Feb 19, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Aaron T MillerCelia Divino
May 7, 2009·The Canadian Journal of Cardiology·Nadia A KhanUNKNOWN Canadian Hypertension Education Program
Oct 15, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kittichai PromratRena R Wing
May 29, 2010·Nature Reviews. Drug Discovery·Edward C Chao, Robert R Henry
Apr 11, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hironori OchiMorikazu Onji
Jul 21, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Siddharth SinghRohit Loomba
Dec 8, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Yuya SekoYoshito Itoh

❮ Previous
Next ❯

Citations

Aug 23, 2020·International Journal of Molecular Sciences·Gianluca Svegliati-BaroniAmalia Gastaldelli
Apr 18, 2019·Diabetes & Metabolism Journal·Kyung Soo KimCheol Young Park
Jul 27, 2020·Endocrinology, Diabetes & Metabolism·Vasiliki Mittag-RoussouCaroline S Stokes
Aug 14, 2020·Clinical and Molecular Hepatology·Kyung-Soo Kim, Byung-Wan Lee
Oct 4, 2020·Diabetes/metabolism Research and Reviews·Francisca Dos Santos CoelhoAdelino Leite-Moreira
Jan 14, 2021·Journal of Gastroenterology and Hepatology·Lampros ChrysavgisEvangelos Cholongitas
Feb 16, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Haleh ChehrehgoshaMohammad E Khamseh
Apr 23, 2021·Expert Review of Clinical Pharmacology·Elizabeth M LamosStephen N Davis
Apr 21, 2021·Diabetologia·Amalia GastaldelliHans-Ulrich Häring
Jul 3, 2021·Journal of Personalized Medicine·Michele FinottiGiacomo Zanus

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies
X-ray

Software Mentioned

FibroScan
JMP

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.