Ipratropium nasal spray in children with perennial rhinitis

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
E O MeltzerK Drda

Abstract

To compare the efficacy and safety of ipratropium nasal spray and placebo administered twice each day for 4 weeks in pediatric patients with perennial rhinitis who had rhinorrhea as a major complaint. This was a multicenter, double-blind, parallel group study. Patients aged 6 to 18 years with symptoms of perennial nonallergic (PNAR) or perennial allergic rhinitis (PAR) were randomized to receive ipratropium (42 micrograms per nostril) or placebo nasal spray, double-blind, twice each day for 4 weeks. Efficacy was evaluated by nasal symptoms, especially anterior rhinorrhea, and quality of life. Previous caregivers for rhinitis and medications used in the past were also evaluated. A total of 202 patients were empanelled, 162 with PAR, 40 with PNAR; of these 151 with mild-severe rhinorrhea were evaluated for efficacy. Treatment with ipratropium reduced symptoms of rhinorrhea primarily in patients with PNAR. In patients with PAR this response was less pronounced, and was seen as a modest decrease in the severity of rhinorrhea noted in the first 2 weeks of treatment. Quality of life assessments confirmed that rhinorrhea was bothersome to these pediatric patients, and suggested that treatment with ipratropium nasal spray was associate...Continue Reading

References

Dec 1, 1979·Clinical Otolaryngology and Allied Sciences·P BorumF Schultz Larsen
Mar 1, 1979·Clinical Allergy·A KnightR Elie
Dec 1, 1992·The Journal of Allergy and Clinical Immunology·R B BerkowitzK Smith
Dec 1, 1992·The Journal of Allergy and Clinical Immunology·D B EnglerJ A Grant
Jun 1, 1992·The Journal of Allergy and Clinical Immunology·F M BaroodyR M Naclerio
Dec 1, 1989·The Journal of Allergy and Clinical Immunology·F E Simons
Nov 1, 1988·The Journal of Allergy and Clinical Immunology·R M Naclerio
Apr 1, 1988·American Family Physician·M E Demichiei, L Nelson
May 1, 1985·European Journal of Orthodontics·A WenzelJ M Henriksen
May 1, 1995·The Journal of Allergy and Clinical Immunology·C C WoodT MacGregor
May 1, 1995·The Journal of Allergy and Clinical Immunology·E A BronskyC C Wood
May 1, 1995·The Journal of Allergy and Clinical Immunology·L DiamondM T Wecker
Nov 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J W GeorgitisC Wood
Oct 1, 1994·The Journal of Allergy and Clinical Immunology·E O MeltzerE A Field
Mar 1, 1994·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WagenmannR M Naclerio

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Citations

May 10, 2005·Immunology and Allergy Clinics of North America·Lien LaiJeffrey Stokes
Feb 11, 2005·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Kenneth T KimUNKNOWN Pediatric Atrovent Nasal Spray Study Group
Sep 10, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H MilgromC C Wood
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M S Blaiss
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·S P Galant, R Wilkinson
Jul 26, 2006·Analytical and Bioanalytical Chemistry·Ivana GazićZrinka Kovarik
Dec 18, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·G K ScaddingUNKNOWN British Society for Allergy and Clinical Immunology
Jul 8, 2009·Current Medical Research and Opinion·Glenis Scadding
Sep 12, 1998·Primary Care·D Weldon
Oct 11, 2005·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John H KrouseDarrell Hunsaker
Feb 14, 2018·International Forum of Allergy & Rhinology·Sarah K WiseMark Zacharek
Jul 6, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zihan JiangJuan Meng

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