PMID: 15374271Nov 1, 1994Paper

Ipriflavone-treatment of senile osteoporosis: results of a multicenter, double-blind clinical trial of 2 years

Archives of Gerontology and Geriatrics
D MaugeriF Ennas

Abstract

Eighty-four out of 100 enrolled female patients affected by osteoporosis completed a double-blind, randomized trial, using ipriflavone (IP) in a dose of 3 x 200 mg/day (41 patients) or placebo (P)(43 patients). All patients received 1 g/day oral calcium supplementation. Inclusion criteria were: age over 65 years; at least one vertebral fracture in the past; bone mineral density measured at the distal tenth of the radius lower than the normal average -2 x S.D. The trial period was between June 1990 and November 1993. Patients of the IP group showed a significant increase in bone mineral density (P < 0.05) compared with the starting values during the whole study period. Pain decreased rapidly, intake of analgesics dropped, and often significant decreases in calciuria, hydroxyprolinuria, alkaline phospatase, osteocalcin and parathormone values were observed. Only two new fractures occurred during the trial in the IP group. Patients of the P group at the end of the study displayed decreased bone mineral densities (P < 0.05), increased pain, greater consumption of analgesics, and often significant increases in the bone metabolism parameters listed for the IP group. In the

References

Mar 1, 1991·Agents and Actions·M L Ferrándiz, M J Alcaraz
Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S BenvenutiM L Brandi
Jul 1, 1991·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·H Orimo
Jan 1, 1990·Immunopharmacology and Immunotoxicology·M T KennyH L Torney
Jun 1, 1990·Biochemical Pharmacology·C V de WhalleyD S Leake
Sep 1, 1989·Journal of Natural Products·M J AlcarazA Villar
Apr 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M TsudaT Fujita
Jan 1, 1985·Archives of Oto-rhino-laryngology·I Sziklai, O Ribári
Apr 1, 1964·British Journal of Pharmacology and Chemotherapy·J E LIGHTOWLER, H J RYLANCE
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Emilie A Bard-ChapeauNeal G Copeland

❮ Previous
Next ❯

Citations

Jan 1, 1997·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S AdamiM Passeri
Jan 1, 1997·Calcified Tissue International·C Gennari
Jan 1, 1997·Calcified Tissue International·D Agnusdei, L Bufalino
Jan 1, 1997·Calcified Tissue International·J Y ReginsterC Roux
Feb 1, 1997·Calcified Tissue International·H Rico
Mar 26, 2002·Climacteric : the Journal of the International Menopause Society·J Ginsburg, G M Prelevic
Jul 9, 2010·Menopause : the Journal of the North American Menopause Society·Rafael Bolaños, José Francia
Jun 1, 2007·Nutrition Research Reviews·T P DewM R A Morgan

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.