Abstract
Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic administration of the Schistosomiasis hematobium-derived protein H-IPSEH06 (IL-4-inducing principle from Schistosoma mansoni eggs) is superior to three doses of MESNA in alleviating hemorrhagic cystitis (Mbanefo EC, Le L, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH. FASEB J 32: 4408-4419, 2018). Based on prior reports by others on S. mansoni IPSE (M-IPSE) and additional work by our group, we reasoned that H-IPSE mediates its effects on hemorrhagic cystitis by binding IgE on basophils and inducing IL-4 expression, promoting urothelial proliferation, and translocating to the nucleus to modulate expression of genes implicated in relieving bladder dysfunction. We speculated that local bladder injection of the S. hematobium IPSE ortholog IPSEH03, hereafter called H-IPSEH03, might be more efficacious in preventing hemorrhagic cystitis compared with systemic administration of IPSEH06. We report that H-IPSEH03, like M-IPSE and H-IPSEH06, activates IgE-bearing basophil...Continue Reading
References
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J D ShepherdG L Phillips
Jun 1, 1986·Japanese Journal of Clinical Oncology·M SakuraiJ R Jett
May 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G L AndrioleI T Magrath
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jun 1, 1993·The Journal of Urology·J E HaderM J Naslund
Jun 7, 2000·The Journal of Urology·M BoucherA Eschalier
Nov 14, 2002·Urology·J OswaldC Radmayr
Jun 20, 2003·European Urology·H Schulte-BauklohH H Knispel
Aug 13, 2003·The Journal of Urology·Karine BonJeffrey S Mogil
Nov 23, 2005·The Journal of Experimental Medicine·Philip SmithPadraic G Fallon
Sep 2, 2006·Cancer Chemotherapy and Pharmacology·Marcos Venício Alves LimaRonaldo Albuquerque Ribeiro
May 2, 2009·Molecular and Biochemical Parasitology·James P HewitsonRick M Maizels
Apr 30, 2010·Journal of Tropical Pediatrics·Kanji WatanabeYoshiki Aoki
Apr 7, 2011·International Neurourology Journal·Gilho Lee
Apr 7, 2011·Inflammation·Francisco Yuri Bulcão MacedoRonaldo A Ribeiro
Dec 1, 2008·Current Protocols in Pharmacology·Liza Leventhal, Brian Strassle
Mar 10, 2012·Gene Therapy·T OguchiN Yoshimura
Apr 6, 2012·PLoS Pathogens·Chi-Ling FuMichael H Hsieh
Mar 20, 2014·Infection and Immunity·Yi-Ju HsiehMichael H Hsieh
Apr 11, 2014·American Journal of Physiology. Renal Physiology·Weiqun YuMark L Zeidel
Sep 12, 2014·American Journal of Physiology. Renal Physiology·Fuat BicerFirouz Daneshgari
Sep 26, 2014·PLoS Neglected Tropical Diseases·Daniel WanFranco H Falcone
Jun 13, 2015·Current Protocols in Mouse Biology·Cheryl L Ackert-BicknellLuanne L Peters
Oct 11, 2015·Current Allergy and Asthma Reports·Franco H FalconeRyosuke Nakamura
Apr 18, 2016·Journal of Biotechnology·Laurence DelafosseYves Durocher
Aug 28, 2016·Urology·Ethan L Matz, Michael H Hsieh
Sep 20, 2017·Infection and Immunity·Luke F PenningtonFranco H Falcone
Apr 4, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Evaristus C MbanefoMichael H Hsieh
Oct 27, 2018·Frontiers in Immunology·Katrin KnuhrGabriele Schramm
Citations
Apr 29, 2020·Infection and Immunity·Junhui LiYingzi Ming
Oct 27, 2020·Infectious Agents and Cancer·Evaristus C MbanefoMichael H Hsieh
Dec 11, 2020·Parasites & Vectors·Evaristus C MbanefoMichael H Hsieh
Dec 22, 2020·Molecular Pain·Kenji IshidaMichael H Hsieh
Mar 12, 2021·Frontiers in Immunology·Yi MuPengfei Cai
Dec 31, 2021·PLoS Pathogens·Sreemoyee AcharyaPatrick J Skelly