Abstract
The aim of this retrospective study was to assess the risk factors for developing ipsilateral breast tumor reappearance (IBTR) and de novo contralateral breast cancer (BC) after primary BC treatment. Retrospectively, 15,168 consecutive patients with primary monolateral BC were enrolled in this monocentric study (from June 1994 to December 2006). Clinicopathological features, follow-up, and survival at 15 years were considered for statistical analysis. Significant associations of increased risk for IBTR were verified with metastatic axillary lymph nodes (HR 1.37 [1.15-1.62], p = 0.0004), high tumor grade G2 (HR 1.35 [1.05-1.74], p = 0.02) and G3 (HR 1.35 [1.01-1.79], p = 0.04), luminal B (HR 1.51 [1.25-1.82], p < 0.0001), and HER2-positive (HR1.66 [1.14-2.41], p = 0.008) and triple-negative subtype (HR 1.54 [1.07-2.21], p = 0.02). Older age (HR 1.44 [1.08-1.91], p = 0.01) and positive family history (HR 1.85 [1.47-2.32], p < 0.0001) were risk factors for contralateral BC. Significant protective factors for IBTR were hormonotherapy (HR 0.71 [0.59-0.85], p = 0.0003), chemotherapy (HR 0.72 [0.60-0.87], p = 0.001), and radiotherapy (HR 0.73 [0.61-0.87], p = 0.0005). Hormonotherapy was also confirmed as a protective factor for contra...Continue Reading
References
Jul 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherR G Margolese
Sep 23, 2003·Epidemiology·Jonine L BernsteinW Douglas Thompson
Oct 17, 2003·American Journal of Clinical Pathology·Neal S GoldsteinFrank Vicini
Sep 29, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alphonse TaghianNorman Wolmark
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Irene L WapnirNorman Wolmark
May 25, 2006·British Journal of Cancer·J S Raymond, C J R Hogue
Jan 18, 2007·The Oncologist·Matthew J HayatBrenda K Edwards
Sep 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mikael HartmanPer Hall
Apr 17, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul L NguyenJay R Harris
Sep 2, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ewan K A MillarRobert L Sutherland
Oct 31, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B BanelliL Del Mastro
Jan 13, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eleftherios P MamounasNorman Wolmark
Sep 8, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nehmat HoussamiLawrence J Solin
Jun 15, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bassam S AbdulkarimSiham Sabri
Jun 15, 2011·Breast Cancer Research and Treatment·Voralak VichapatMargreet Lüchtenborg
Mar 26, 2013·The Breast : Official Journal of the European Society of Mastology·Eirene C BehmJohn M Buckingham
Nov 15, 2013·The Lancet Oncology·Umberto VeronesiBettina Ballardini
Aug 17, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Monica MorrowMeena S Moran
Jan 27, 2017·Journal of the National Cancer Institute·Eleftherios P MamounasNorman Wolmark
Jun 4, 2017·Breast Cancer Research and Treatment·Gulisa TurashviliHannah Y Wen
Jul 19, 2017·Journal of Global Oncology·Barbara G SilvermanLital Keinan-Boker
Aug 3, 2017·Annals of Surgical Oncology·Megan E MillerKimberly J Van Zee
Sep 19, 2017·International Journal of Cancer. Journal International Du Cancer·Colin B BeggJorge S Reis-Filho
Nov 9, 2017·The New England Journal of Medicine·Hongchao PanUNKNOWN EBCTCG
Citations
Feb 28, 2020·Annals of Surgical Oncology·Giovanni Corso
Jan 23, 2020·Annals of Surgical Oncology·Giovanni CorsoPaolo Veronesi
Apr 2, 2021·Cancer·Giovanni CorsoPaolo Veronesi
Jun 29, 2021·Updates in Surgery·Damiano GentileCorrado Tinterri
Jun 18, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Jin WangKevin S Hughes
Aug 20, 2021·Cancer Management and Research·Yujie LuKunwei Shen