Ipsilateral deficits of dopaminergic neurotransmission in Parkinson's disease

Annals of Clinical and Translational Neurology
Valtteri Kaasinen

Abstract

The nigral lesion and the resulting contralateral motor signs of Parkinson's disease (PD) are remarkably asymmetric. This study investigated the prevalence of patients with "wrong-sided" lesions, that is, patients with symptoms on the side ipsilateral to the predominant dopaminergic nigrostriatal deficit. The analyzed sample included 434 early unmedicated PD patients from the Parkinson's Progression Markers Initiative database. Asymmetry indices of motor function and putamen [(123)I]FP-CIT SPECT were calculated from the screening visit data. Ipsilateral deficits were unexpectedly common even when only patients with clear motor and dopaminergic asymmetries were included in the analysis (8.1%, n = 24/295). When patients with any asymmetry were included in the analysis, the prevalence of ipsilateral deficits was 15.4% (n = 65/423). Wrong-sided symptoms were not associated with the PD motor subtype. However, the dataset was heavily biased toward tremor-dominant patients (85% of patients). Right-handed PD patients had predominantly right-sided motor symptoms and left-sided dopamine defects, whereas the effect was opposite in left-handed patients (P = 0.005 and 0.028, respectively). The results indicate that the side of the predomina...Continue Reading

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Citations

Jul 18, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Pei HuangSheng-Di Chen
Oct 1, 2019·Nuclear Medicine Communications·Atsutaka OkizakiMichihiro Nakayama
Apr 16, 2018·Cell and Tissue Research·P RiedererR Krüger
Feb 13, 2019·Movement Disorders Clinical Practice·Seyed-Mohammad FereshtehnejadRonald B Postuma
Apr 9, 2019·Journal of Parkinson's Disease·Jason Massa, Lana M Chahine
Jul 16, 2017·Scientific Reports·A K M Rezaul KarimNaima Nigar
Nov 28, 2019·Deutsches Ärzteblatt International·Ralph BuchertJürgen Gallinat
Feb 27, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Georgia SousouriEsther Werth
Jun 15, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Eleonora FiorenzatoRoberta Biundo
Aug 24, 2021·EJNMMI Research·Emma A HonkanenValtteri Kaasinen

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Clinical Trials Mentioned

NCT01141023

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