PMID: 11905457Mar 22, 2002Paper

Ipsilateral local recurrence of breast cancer: determinant or indicator of poor prognosis?

The Lancet Oncology
G Querci della Rovere, John R Benson

Abstract

The importance of ipsilateral local recurrence within a conserved breast depends on the micrometastatic environment at the time of initial clinical presentation. In the absence of micrometastases, local recurrence would be a determinant of distant disease; however, in the presence of micrometastases, it represents a marker of distant relapse. Maximum locoregional treatment at primary diagnosis would be appropriate in the former group, whereas minimum treatment would be sufficient in the latter group, with full treatment prescribed at the time of local recurrence. As an indicator of poor prognosis, the presence of local recurrence permits a more selective approach to therapies that would otherwise result in overtreatment for some patients. We, therefore propose a trial that compares conventional treatment with minimum therapy at presentation plus maximum therapy at local relapse in postmenopausal women with small tumours.

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Citations

Mar 14, 2003·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·D A Rew
Jan 9, 2003·The Lancet Oncology·John R BensonMitsuhiro Hayashi
Apr 29, 2005·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yoshifumi KomoikeHideo Inaji
Mar 7, 2012·World Journal of Surgery·John R Benson, Katy A T Teo
Jul 25, 2009·The Breast : Official Journal of the European Society of Mastology·Takashi YoshidaToshio Tabei
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·José A López-GuerreroAntonio Llombart-Bosch
Apr 19, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Mio KitagawaKoh-Ichi Sakata
Jun 2, 2021·The British Journal of Surgery·R VidyaC Holcombe

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