Iptakalim inhibits nicotine-induced enhancement of extracellular dopamine and glutamate levels in the nucleus accumbens of rats

Brain Research
Qiang LiuGang Hu

Abstract

Iptakalim (Ipt) is a novel ATP-sensitive potassium channel opener. It has been reported that Ipt inhibited cocaine-induced dopamine and glutamate release, suggesting that Ipt may regulate drug addiction. Recently, we found that Ipt blocked nicotinic acetylcholine receptor (nAChR)-mediated currents in a heterologously expressed SH-EP1 cell line and in native midbrain dopamine neurons. In the present study, we examined whether Ipt prevents nicotine-induced neurotransmitter release in the nucleus accumbens (NAc) using in vivo microdialysis methods in awake, freely moving rats. Ipt was administered through a microdialysis probe, following systemic administration of nicotine (0.5 mg/kg, s.c.). The results show that acute nicotine treatment induced an increase of both dopamine and glutamate levels in the rat NAc, and that Ipt significantly attenuated nicotine's effects in a concentration-dependent manner. Therefore, Ipt may serve as a novel compound to block nicotine-induced dopamine and glutamate release in the brain reward center, in turn decreasing nicotine reinforcement and dependence.

References

Aug 23, 2001·Neuron·J A DaniF M Zhou
Oct 22, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·James D BelluzziFrances M Leslie

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Citations

Jul 30, 2014·Neuroscience and Biobehavioral Reviews·Katharine A BrennanPenelope Truman
Nov 26, 2015·Frontiers in Neuroscience·Manoranjan S D'Souza
Sep 4, 2007·Biochemical Pharmacology·Karen K SzumlinskiKevin D Lominac
Feb 23, 2013·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Nick VolfMing Li
Mar 3, 2009·Journal of Psychopharmacology·K A BrennanP Truman

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