PMID: 11916348Mar 28, 2002Paper

IQ (2-amino-3-methylimidazo[4,5-f]quinoline)-induced aberrant crypt foci and colorectal tumour development in rats fed two different carbohydrate diets

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
A M MølckI Thorup

Abstract

In most aberrant crypt foci (ACF) and colorectal tumour studies, chemical carcinogens not normally found in food have been used as initiators. In the present study the food-related compound, IQ (2-amino-3-methylimidazo[4,5-f]quinoline), has been used. A diet high in refined carbohydrates has been associated with enhanced development of ACF and colorectal cancer in humans. The present study was designed as an integrated part of our earlier published ACF study and follows the animals until tumour development. The aim of the study was to investigate (1) the effect of a refined carbohydrate-rich diet on the development of IQ-induced ACF over time and (2) possible correlation between early and late ACF and/or colorectal tumour development. The study showed that a feeding regimen with continuous doses of 0.03% IQ in the diet for 14 weeks, followed by 32 weeks without IQ was able to induce tumours in the rat colon, liver, skin and Zymbal gland. The data demonstrate that a sucrose-rich diet enhance ACF development. A correlation between the outcome of early and late ACF was seen. However, as the tumour incidence of this study was very low it was not possible to obtain a meaningful correlation between ACF development and colorectal tumo...Continue Reading

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Citations

Aug 23, 2003·European Journal of Medicinal Chemistry·Martijn VermeulenHans Verhagen
Sep 29, 2004·Mutation Research·Max HansenLars O Dragsted
Aug 9, 2005·Mutation Research·Lotte RisomSteffen Loft
Oct 19, 2006·Nutrition and Cancer·Helene JacobsenRikke Hvid Lindecrona
Nov 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anat LevitMasha Y Niv
Jun 8, 2007·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Jay H Fowke
May 2, 2002·Anti-cancer Drugs·Paul J Thornalley
Jul 3, 2002·Epidemiology·Robert Millikan
Oct 3, 2002·Annual Review of Pharmacology and Toxicology·Truyen NguyenCecil B Pickett
Mar 28, 2020·Nutrients·Luigi Mandrich, Emilia Caputo
Feb 24, 2011·The British Journal of Nutrition·Fei LiJohanna W Lampe
May 14, 2020·Natural Product Reports·Donna D Zhang, Eli Chapman
Dec 3, 2013·Natural Product Reports·Hemant KumarDong-Kug Choi
Aug 23, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Natalia MiękusArtur H Świergiel
Nov 5, 2014·Antioxidants & Redox Signaling·Stephanie M TortorellaTom C Karagiannis
Sep 1, 2016·Frontiers in Nutrition·Francisco J BarbaMohamed Koubaa

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