IQ predictors in pediatric opsoclonus myoclonus syndrome: a large international cohort study.

Developmental Medicine and Child Neurology
Andrew SheridanMark P Gorman

Abstract

To determine predictors of full-scale IQ (FSIQ) in an international pediatric opsoclonus myoclonus syndrome (OMS) cohort. In this retrospective and prospective cohort study at three academic medical centers (2006-2013), the primary outcome measure, FSIQ, was categorized based on z-score: above average (≥+1), average (+1 to -1), mildly impaired (-1 to -2), and impaired (<-2). Univariate analysis and multivariable linear regression modeling using stepwise selection with Akaike's information criterion was performed to understand the relationship between exposures and FSIQ. Of 81 participants, 37 with sufficient data had mean FSIQ 84.38 (SD 20.55) and median 90 (40-114) at latest available evaluation (mean age 8y 5mo). Twenty (54%), nine (24.3%), and eight (21.6%) had normal, mildly impaired, and impaired FSIQ respectively. The final multivariable linear regression model included 34 participants with evaluable data: number of relapses occurring before neuropsychological testing (p<0.001) and OMS severity score at last follow-up (p<0.001) predicted FSIQ (adjusted R2 =0.64). There was a mean decrease of 2.4 FSIQ points per OMS relapse. Number of relapses negatively correlates with FSIQ in pediatric OMS. Demographic and clinical measu...Continue Reading

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Citations

Sep 27, 2020·Developmental Medicine and Child Neurology·Juliette Hukin
Mar 30, 2021·Journal of Neurology·Poonam BhatiaMichael C Kruer
Apr 10, 2021·Current Problems in Pediatric and Adolescent Health Care·Joanna Blackburn, Mered Parnes

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