IQGAP1 modulates the proliferation and migration of vascular smooth muscle cells in response to estrogen

International Journal of Molecular Medicine
Xianchen HuangLiming Shen

Abstract

Vascular smooth muscle cell (VSMC) proliferation and migration has been proven to be a critical event in the development of varicosity. Variations in estrogen levels, a pathological event related to age and pregnancy, play a role in the pathogenesis of varicosity. Previous studies have reported a different response of VSMCs following estrogen stimulation. However, the exact mechanisms involved have not yet been elucidated. In the present study, we examined the responses of lesion and normal VSMCs treated with 10(-8) M 17β-estradiol (E2) for 24 h. A differential effect of exposure to E2 was observed in these cells. IQ-domain GTPase-activating protein 1 (IQGAP1), a scaffold protein, was overexpressed in the lesion VSMCs and was shown to modulate VSMC proliferation and migration in response to E2. Furthermore, the increased expression of IQGAP1 was found to be intimately associated with a high activity of estrogen receptor α (ERα), which has been implicated in the regulation of VSMC physiological function. Additionally, we found that two critical kinases, Akt and extracellular signal-regulated kinase (ERK), mediated the activation of ERα and VSMC proliferation. According to our results, we thus concluded that high levels of IQGAP1...Continue Reading

References

Jul 31, 1976·Lancet·J T Hobbs
May 1, 1994·The Journal of Dermatologic Surgery and Oncology·A Cornu-ThenardP H Carpentier
Mar 26, 2003·Journal of Clinical Epidemiology·Amanda J LeeF Gerald R Fowkes
Mar 29, 2003·Journal of Vascular Surgery·Patrick H CarpentierUNKNOWN European Working Group on the Clinical Characterization of Venous Disorders
Aug 6, 2003·The Journal of Biological Chemistry·Jennifer M MatarazaDavid B Sacks
Feb 19, 2004·The Journal of Biological Chemistry·Monideepa RoyDavid B Sacks
May 14, 2005·Journal of Cell Science·Jun NoritakeKozo Kaibuchi
Jun 29, 2005·Archives of Internal Medicine·Robert D LangerMichael H Criqui
Sep 2, 2005·Molecular and Cellular Biology·Monideepa RoyDavid B Sacks
Dec 13, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·W M RennoM Wali
Jun 15, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jian-Guo RenDavid B Sacks
Jul 7, 2007·Physiological Reviews·Nina HeldringJan-Ake Gustafsson
Nov 7, 2007·The Journal of Biological Chemistry·Darerca OwenHelen R Mott
Jun 13, 2009·Breast Cancer Research : BCR·Joan S Lewis-Wambi, V Craig Jordan
Aug 26, 2009·Journal of Vascular Surgery·Ying XiaoShenming Wang
Sep 30, 2009·Molecular and Cellular Endocrinology·Xiaohong JiangChen-Yu Zhang
Feb 27, 2010·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Radoslaw KowalewskiMarek Gacko
Dec 21, 2011·Cellular Signalling·Colin D WhiteDavid B Sacks
Mar 22, 2012·Journal of Vascular Research·Hai-Chao Han
Nov 24, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Jin ZhaoRichard H Karas
Dec 27, 2012·JAMA : the Journal of the American Medical Association·Allen Hamdan
Jun 8, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazutaka UedaRichard H Karas
Aug 30, 2013·Cardiovascular Research·Emanuela BranchettiGiovanni Ferrari
Feb 20, 2014·The Journal of Biological Chemistry·Huseyin H ErdemirDavid B Sacks

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