IR, UV-Vis, magnetic and thermal characterization of chelates of some catecholamines and 4-aminoantipyrine with Fe(III) and Cu(II)

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Gehad G MohamedR G el-Nahas

Abstract

The dopamine derivatives participate in the regulation of wide variety of physiological functions in the human body and in medication life. Increase and/or decrease in the concentration of dopamine in human body reflect an indication for diseases such as Schizophrenia and/or Parkinson diseases. Alpha-methyldopa (alpha-MD) in tablets is used in medication of hypertension. The Fe(III) and Cu(II) chelates with coupled products of adrenaline hydrogen tartarate (AHT), levodopa (LD), alpha-MD and carbidopa (CD) with 4-aminoantipyrine (4-AAP) are prepared and characterized. Different physico-chemical methods like IR, magnetic and UV-Vis spectra are used to investigate the structure of these chelates. Fe(III) form 1:2 (M:catecholamines) chelates while Cu(II) form 1:1 chelates. Catecholamines behave as a bidentate mono- or dibasic ligands in binding to the metal ions. IR spectra show that the catecholamines are coordinated to the metal ions in a bidentate manner with O,O donor sites of the phenolic -OH. Magnetic moment measurements reveal the presence of Fe(III) chelates in octahedral geometry while the Cu(II) chelates are square planar. The thermal decomposition of Fe(III) and Cu(II) complexes is studied using thermogravimetric (TGA) a...Continue Reading

References

Jan 1, 1992·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·S KaakkolaP T Männistö
Jul 11, 2000·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Z M Zaki, G G Mohamed

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Citations

Jul 29, 2011·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Gehad G MohamedR G el-Nahas
Jan 3, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·M A ZayedM A Fahmey
Oct 27, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Qingming WangXueqi Fu

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