Iranian HIV/AIDS patients with oropharyngeal candidiasis: identification, prevalence and antifungal susceptibility of Candida species

Letters in Applied Microbiology
S KhedriS Kalantari

Abstract

Oropharyngeal candidiasis is the commonest mucocutaneous infection in HIV-positive individuals. Herein, samples were taken from oral cavities of 150 HIV-infected patients and cultured on Sabouraud-dextrose agar; 89 (59·3%) of 150 patients had positive culture for Candida and presented clinical sign of classical oral candidiasis. Totally, 102 morphologically distinct colonies were isolated from Candida positive cultures and subsequently identified by polymerase chain reaction and sequencing assay, presenting the following frequency: 54 C. albicans (52·9%), 16 C. dubliniensis (15·7%), 12 C. tropicalis (11·8%), 9 C. glabrata (8·8%), 7 C. kefyr (6·9%) and 4 C. africana (3·9%). Additionally, multiple Candida species were co-isolated from 13·5% (12/89) patients. Regarding the antifungal susceptibility test, which was performed by CLSI protocol (M27-A3/M27-S3), all Candida isolates were susceptible to amphotericin B and caspofungin, while some of them were resistant to fluconazole (17·6%; 16 C. albicans, 1 C. dubliniensis and 1 C. glabrata), itraconazole (16·7%; 15 C. albicans, 1 C. dubliniensis and 1 C. tropicalis) and voriconazole (5·9%; 5 C. albicans and 1 C. tropicalis). Collectively, our findings reinforce the urgent necessity to...Continue Reading

References

Sep 1, 1995·Journal of Medical and Veterinary Mycology : Bi-monthly Publication of the International Society for Human and Animal Mycology·K A HaynesW Moens
Feb 16, 2000·Oral Diseases·D W Williams, M A Lewis
May 8, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S WalmsleyS Richardson
Jan 10, 2002·Infectious Disease Clinics of North America·M A Pfaller, W L Yu
Oct 19, 2004·Clinical Microbiology Reviews·Louis de RepentignyPaul Jolicoeur
Aug 27, 2005·Oral Diseases·N S Soysa, A N B Ellepola
Oct 11, 2005·FEMS Microbiology Letters·Derek J SullivanDavid C Coleman
Jan 21, 2009·Drug Discovery Today·Katharina GauwerkyHans C Korting
Jul 30, 2010·Mycoses·Orazio Romeo, Giuseppe Criseo
Mar 1, 2012·Revista Do Instituto De Medicina Tropical De São Paulo·Juliana C JunqueiraAntonio Olavo C Jorge
Aug 28, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Jiun-Nong LinHsiu-Jung Lo
Jul 24, 2013·BioMed Research International·Claudia Spampinato, Darío Leonardi
Mar 25, 2014·Lancet·Mohammad KaramouzianAli Akbar Haghdoost
Apr 15, 2014·Diagnostic Microbiology and Infectious Disease·Pedro Miguel Dos Santos AbrantesCharlene Wilma Joyce Africa
Oct 30, 2014·Revista Do Instituto De Medicina Tropical De São Paulo·Edileusa Rosa dos SantosSydney Hartz Alves

❮ Previous
Next ❯

Citations

Jan 17, 2021·International Microbiology : the Official Journal of the Spanish Society for Microbiology·Rong ChengZhenhua Luo

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.