Ire1 supports normal ER differentiation in developing Drosophila photoreceptors

Journal of Cell Science
Zuyuan XuDonald F Ready

Abstract

The endoplasmic reticulum (ER) serves virtually all aspects of cell physiology and, by pathways that are incompletely understood, is dynamically remodeled to meet changing cell needs. Inositol-requiring enzyme 1 (Ire1), a conserved core protein of the unfolded protein response (UPR), participates in ER remodeling and is particularly required during the differentiation of cells devoted to intense secretory activity, so-called 'professional' secretory cells. Here, we characterize the role of Ire1 in ER differentiation in the developing Drosophila compound eye photoreceptors (R cells). As part of normal development, R cells take a turn as professional secretory cells with a massive secretory effort that builds the photosensitive membrane organelle, the rhabdomere. We find rough ER sheets proliferate as rhabdomere biogenesis culminates, and Ire1 is required for normal ER differentiation. Ire1 is active early in R cell development and is required in anticipation of peak biosynthesis. Without Ire1, the amount of rough ER sheets is strongly reduced and the extensive cortical ER network at the rhabdomere base, the subrhabdomere cisterna (SRC), fails. Instead, ER proliferates in persistent and ribosome-poor tubular tangles. A phase of I...Continue Reading

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Citations

May 1, 2016·Trends in Neurosciences·Juliette D GodinLaurent Nguyen
Apr 6, 2017·International Journal of Molecular Sciences·Wai Chin ChongRajaraman Eri
Feb 1, 2020·Wiley Interdisciplinary Reviews. Developmental Biology·Chase C WesleyDaniel L Levy
Nov 29, 2017·Journal of Cell Science·Shweta YadavPadinjat Raghu
Apr 11, 2018·Molecular and Cellular Biology·Eunice Domínguez-MartínRicardo Escalante

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Methods Mentioned

BETA
electron microscopy
confocal microscopy
Transgenic
electron
transmission electron microscopy

Software Mentioned

pUAST
ImageJ
IMOD

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