IRES mediated translational regulation of p53 isoforms

Wiley Interdisciplinary Reviews. RNA
A SharathchandraSaumitra Das

Abstract

p53 is a well known tumor suppressor protein that plays a critical role in cell cycle arrest and apoptosis. It has several isoforms which are produced by transcriptional and posttranscriptional regulatory mechanisms. p53 mRNA has been demonstrated to be translated into two isoforms, full-length p53 (FL-p53) and a truncated isoform ΔN-p53 by the use of alternative translation initiation sites. The mechanism of translation regulation of these two isoforms was further elucidated by the discovery of IRES elements in the p53 mRNA. These two IRESs were shown to regulate the translation of p53 and ΔN-p53 in a distinct cell-cycle phase-dependent manner. This review focuses on the current understanding of the regulation of p53 IRES mediated translation and the role of cis and trans acting factors that influence expression of p53 isoforms.

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Citations

Jun 17, 2016·Molecular & Cellular Oncology·Debjit KhanSaumitra Das
Jan 6, 2017·International Journal of Molecular Sciences·Bai JiDa-Qing Yang
Dec 19, 2017·F1000Research·Sue Haupt, Ygal Haupt
Aug 29, 2018·Cancers·Maximilian Vieler, Suparna Sanyal
Dec 15, 2019·International Journal of Molecular Sciences·Thineskrishna Anbarasan, Jean-Christophe Bourdon
Jul 12, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Marina KazantsevaAntony W Braithwaite
May 3, 2019·Nucleic Acids Research·Sarit CohenEyal Arbely
Aug 1, 2019·BMC Bioinformatics·Junhui Wang, Michael Gribskov
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Dec 4, 2016·Cancer Research·Sunali MehtaCristin Print
May 5, 2021·Database : the Journal of Biological Databases and Curation·Tzu-Hsien YangCheng-Tse Liu
Jun 8, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Gayatri MohananPurusharth I Rajyaguru

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