IRF5 is increased in labouring myometrium and regulates pro-labour mediators

Reproduction : the Official Journal of the Society for the Study of Fertility
Ratana LimMartha Lappas

Abstract

Preterm birth continues to be the leading cause of neonatal mortality and morbidities that can extend into adult life. Few treatment options stem from our incomplete understanding of the mechanisms of human labour and delivery. Activation of the inflammatory response in gestational tissues by inflammation and/or infection leads to the production of pro-inflammatory and pro-labour mediators, thus preterm birth. Interferon regulatory factor 5 (IRF5) has recently emerged as an important pro-inflammatory transcription factor involved in acute and chronic inflammation. The aims of this study were to determine the expression of IRF5 in human myometrium from labouring and non-labouring women, and whether IRF5 is involved in the genesis of pro-inflammatory and pro-labour mediators induced by pro-inflammatory cytokines or toll-like receptor (TLR) ligands. IRF5 mRNA and protein expression was significantly higher in human myometrium after spontaneous term labour, compared to non-labouring tissues. IRF5 mRNA expression was also significantly higher in primary myometrial cells treated with the pro-inflammatory cytokines IL1B or TNF. In primary myometrial cells, IRF5 knockdown by siRNA (siIRF5) was associated with significantly decreased ex...Continue Reading

References

Mar 29, 2000·American Journal of Reproductive Immunology : AJRI·P N Rauk, J P Chiao
Mar 29, 2001·American Journal of Reproductive Immunology : AJRI·P N RaukJ P Chiao
Jun 7, 2003·Science·Gregory M Barton, Ruslan Medzhitov
Sep 16, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·David M Olson
Nov 3, 2005·Reproduction : the Official Journal of the Society for the Study of Fertility·Tamsin M Lindström, Phillip R Bennett
Jul 15, 2006·Seminars in Fetal & Neonatal Medicine·Roberto RomeroJyh Kae Nien
Aug 26, 2006·Nature Reviews. Immunology·Kenya Honda, Tadatsugu Taniguchi
Jan 8, 2008·Lancet·Robert L GoldenbergRoberto Romero
Mar 14, 2008·Molecular Human Reproduction·Z LiangM R Johnson
Mar 28, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Mark TattersallMark R Johnson
Jun 14, 2008·Journal of Reproductive Immunology·Inge ChristiaensDavid M Olson
Jan 6, 2009·American Journal of Obstetrics and Gynecology·Shrikant BollapragadaScott Nelson
Jul 25, 2009·Molecular Human Reproduction·M YuanJ E Norman
Mar 20, 2010·Blood·Thomas KrausgruberIrina A Udalova
Apr 30, 2010·Bulletin of the World Health Organization·Stacy BeckPaul F A Van Look
May 11, 2010·American Journal of Obstetrics and Gynecology·Carl P WeinerCatalin S Buhimschi
May 22, 2010·Archives of Disease in Childhood. Fetal and Neonatal Edition·Stavros PetrouLindsay Mangham
Sep 17, 2010·Biology of Reproduction·Martha LappasMichael Permezel
Oct 5, 2010·Reproductive Sciences·Sam MesianoErrol R Norwitz
Jan 18, 2011·Nature Immunology·Thomas KrausgruberIrina A Udalova
Feb 10, 2011·Arthritis and Rheumatism·Yoshifumi TadaKohei Nagasawa
May 18, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Rafah Salloum, Timothy B Niewold
Mar 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuan XuWestley H Reeves
May 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matija Hedl, Clara Abraham
May 15, 2012·Lancet·Li LiuUNKNOWN Child Health Epidemiology Reference Group of WHO and UNICEF
May 23, 2012·Reproductive Sciences·Oksana ShynlovaStephen J Lye
Jul 31, 2013·Journal of Perinatal Medicine·Piya ChaemsaithongTinnakorn Chaiworapongsa
Jan 24, 2014·Mediators of Inflammation·Miriam WeissIrina A Udalova
Feb 19, 2014·Expert Opinion on Pharmacotherapy·Elvira O G van VlietMartijn A Oudijk
Apr 11, 2014·Expert Opinion on Investigational Drugs·Sebastián E IllanesMurray D Mitchell
May 9, 2014·Biochimica Et Biophysica Acta·Guang-Nian ZhaoHongliang Li
Aug 28, 2014·Cell Reports·David G SalibaIrina A Udalova
Oct 19, 2014·Proceedings of the National Academy of Sciences of the United States of America·Junyao RenZhijian J Chen

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Citations

Apr 7, 2021·Molecular Human Reproduction·Nawrah KhaderJennifer A Mitchell

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