Abstract
Particulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as lung, brain and liver. However, its effects on renal injury and the underlying molecular mechanism have not been understood. The inactive rhomboid protein 2 (iRhom2), also known as rhomboid family member 2 (Rhbdf2), is a necessary modulator for shedding of tumor necrosis factor-α (TNF-α) in immune cells, and has been explored in the pathogenesis of chronic renal diseases. In the present study, we found that compared to the wild type (iRhom2+/+) mice, iRhom2 knockout (iRhom2-/-) protected PM2.5-exposed mice from developing severe renal injury, accompanied with improved renal pathological changes and functions. iRhom2-/- mice exhibited reduced inflammatory response, as evidenced by the reduction of interleukin 1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and IL-18 in kidney samples, which might be, at least partly, through inactivating TNF-α converting enzyme/TNF-α receptors (TACE/TNFRs) and inhibitor of α/nuclear factor κ B (IκBα/NF-κB) signaling pathways. In addition, oxidative stress was also restrained by iRhom2-/- in kidney of PM2.5-exposed mice by enhancing heme oxygenase/nuclear factor erythroid 2-related factor 2 (HO-1/Nrf-2...Continue Reading
Citations
Nov 24, 2019·Scientific Reports·Hermes Reyes-CaballeroShyam Biswal
Mar 18, 2020·Aging·Chenxu GeMinxuan Xu
Jun 28, 2020·Environmental Science and Pollution Research International·Cuiying LiuXiaokun Geng
Sep 12, 2020·International Journal of Molecular Sciences·Mazin A Al-Salihi, Philipp A Lang
Jun 2, 2020·Journal of Veterinary Science·Meng LiXingxiao Zhang
Dec 4, 2020·Redox Report : Communications in Free Radical Research·Junxia FengYunfang Zhang
Jan 12, 2021·International Immunopharmacology·Ge ChenxuXu Minxuan
Aug 31, 2020·Redox Biology·Chenxu GeMinxuan Xu
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Ramasatyaveni GeesalaThorsten Maretzky
Dec 11, 2020·BMC Complementary Medicine and Therapies·Cong ZhouFurong Lu
Jul 21, 2020·Environmental Pollution·Miao LiuXiaomin Zhang
Apr 2, 2021·Reviews on Environmental Health·Liwei YangLin Ye
Apr 21, 2021·Journal of Agricultural and Food Chemistry·Xueyan WuGuang Yang
Jun 4, 2020·Physiology International·X MengXinjian Li
Dec 24, 2021·Nature Immunology·Satoshi KuboMichael J Lenardo
Jan 22, 2022·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yongheng GaoFaguang Jin
Feb 1, 2022·Human & Experimental Toxicology·Wenqi ChenRuijin Li