iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress

Redox Biology
Ge ChenxuTan Jun

Abstract

Particulate matter (PM2.5) is a risk factor for organ injury and disease progression, such as lung, brain and liver. However, its effects on renal injury and the underlying molecular mechanism have not been understood. The inactive rhomboid protein 2 (iRhom2), also known as rhomboid family member 2 (Rhbdf2), is a necessary modulator for shedding of tumor necrosis factor-α (TNF-α) in immune cells, and has been explored in the pathogenesis of chronic renal diseases. In the present study, we found that compared to the wild type (iRhom2+/+) mice, iRhom2 knockout (iRhom2-/-) protected PM2.5-exposed mice from developing severe renal injury, accompanied with improved renal pathological changes and functions. iRhom2-/- mice exhibited reduced inflammatory response, as evidenced by the reduction of interleukin 1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and IL-18 in kidney samples, which might be, at least partly, through inactivating TNF-α converting enzyme/TNF-α receptors (TACE/TNFRs) and inhibitor of α/nuclear factor κ B (IκBα/NF-κB) signaling pathways. In addition, oxidative stress was also restrained by iRhom2-/- in kidney of PM2.5-exposed mice by enhancing heme oxygenase/nuclear factor erythroid 2-related factor 2 (HO-1/Nrf-2...Continue Reading

Citations

Sep 12, 2020·International Journal of Molecular Sciences·Mazin A Al-Salihi, Philipp A Lang
Dec 4, 2020·Redox Report : Communications in Free Radical Research·Junxia FengYunfang Zhang
Dec 18, 2020·Frontiers in Cardiovascular Medicine·Ramasatyaveni GeesalaThorsten Maretzky
Jul 21, 2020·Environmental Pollution·Miao LiuXiaomin Zhang
Apr 2, 2021·Reviews on Environmental Health·Liwei YangLin Ye
Apr 21, 2021·Journal of Agricultural and Food Chemistry·Xueyan WuGuang Yang
Jan 22, 2022·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yongheng GaoFaguang Jin
Feb 1, 2022·Human & Experimental Toxicology·Wenqi ChenRuijin Li

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
Protein Assay
X-ray
ELISA
transfection

Software Mentioned

GraphPad
ImageJ
GraphPad PRISM

Related Concepts

Related Feeds