Iridium alters immune balance between T helper 1 and T helper 2 responses

Human & Experimental Toxicology
Ivo IavicoliE J Calabrese

Abstract

The recent introduction of iridium (Ir) into the catalytic converter has resulted in an increase of Ir levels into the environment, especially ambient air and soil. These observations suggested the need to evaluate potential toxicity due to Ir exposure. Since Ir compounds have been previously shown to cause immune sensitization in humans, the effects of Ir via drinking water for 90 days was assessed in adult female Wistar rats with respect to selected immune parameters. The Ir exposure induced dose-dependent decrease (p < .01) in T helper 1 (Th1) cytokines and increase (p < .001) in a T helper 2 (Th2) cytokine. The findings show that the Ir exposure affects an immune imbalance with a skewing toward a Th2 bias, a risk factor for asthma.

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Citations

Jun 15, 2011·Environmental Science & Technology·Tseren-Ochir Soyol-ErdeneSoon Do Hur
Jul 19, 2011·Ecotoxicology and Environmental Safety·Ivo IavicoliEdward J Calabrese
Sep 4, 2012·Dose-response : a Publication of International Hormesis Society·Ivo IavicoliAlessandro Alimonti
Apr 24, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Ivo IavicoliAlessandro Sgambato
Feb 26, 2019·Royal Society Open Science·Xingyu QuYang Bai

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