Iridoids and sesquiterpenoids of Valeriana stenoptera and their effects on NGF-induced neurite outgrowth in PC12 cells

Phytochemistry
Fa-Wu DongJiang-Miao Hu

Abstract

Twenty-one compounds (nine iridoids and twelve sesquiterpenoids), including ten previously unknown (five iridoids and five sesquiterpenoids) were isolated from whole dried material of Valeriana stenoptera. Structures were established on the basis of extensive spectroscopic analysis and the relative stereochemistry of 13-hydroxypatchoulol A was further confirmed by X-ray crystallographic data. All isolates were evaluated for their effects on nerve growth factor (NGF)-mediated neurite outgrowth in pheochromocytoma (PC12) cells and seven compounds showed potent promoting effects.

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Citations

May 1, 2017·Fitoterapia·Zhen-Hua LiuJun Zhou
Feb 8, 2019·Journal of Asian Natural Products Research·Fa-Wu DongHong-Ping He
Feb 26, 2019·Chemistry & Biodiversity·Li-Qiu QuanHong-Mei Li
May 23, 2020·Chemistry : a European Journal·Houchao Xu, Jeroen S Dickschat

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