Iridophores and their interactions with other chromatophores are required for stripe formation in zebrafish

Development
Hans Georg FrohnhöferC Nüsslein-Volhard

Abstract

Colour patterns of adult fish are produced by several types of pigment cells that distribute in the dermis during juvenile development. The zebrafish, Danio rerio, displays a striking pattern of dark stripes of melanophores interspersed by light stripes of xanthophores. Mutants lacking either cell type do not form proper stripes, indicating that interactions between these two chromatophore types are required for stripe formation. A third cell type, silvery iridophores, participates to render a shiny appearance to the pattern, but its role in stripe formation has been unclear. Mutations in rose (rse) or shady (shd) cause a lack or strong reduction of iridophores in adult fish; in addition, the melanophore number is drastically reduced and stripes are broken up into spots. We show that rse and shd are autonomously required in iridophores, as mutant melanophores form normal sized stripes when confronted with wild-type iridophores in chimeric animals. We describe stripe formation in mutants missing one or two of the three chromatophore types. None of the chromatophore types alone is able to create a pattern but residual stripe formation occurs with two cell types. Our analysis shows that iridophores promote and sustain melanophores...Continue Reading

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Citations

Apr 30, 2014·Nature Cell Biology·Ajeet Pratap SinghChristiane Nüsslein-Volhard
Oct 10, 2014·Nature Communications·M Emília SantosWalter Salzburger
Jul 11, 2014·General and Comparative Endocrinology·Ingo Braasch, Manfred Schartl
Jan 21, 2015·Current Biology : CB·Ajeet Pratap Singh, Christiane Nüsslein-Volhard
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Apr 16, 2014·Pigment Cell & Melanoma Research·Shinya InoueMasakatsu Watanabe
Aug 4, 2015·Pigment Cell & Melanoma Research·José Miguel Cerdá-ReverterRobert N Kelsh
Mar 25, 2016·ACS Synthetic Biology·Salva Duran-Nebreda, Ricard V Solé
Nov 5, 2014·Pigment Cell & Melanoma Research·Shigeru Kondo, Masakatsu Watanabe
Nov 26, 2014·Pigment Cell & Melanoma Research·David M Parichy, Jessica E Spiewak
Jun 21, 2015·Cellular and Molecular Life Sciences : CMLS·Chrysovalantou FanikuPatricia E Martin
Sep 13, 2014·Science·Prateek MahalwarChristiane Nüsslein-Volhard
Aug 30, 2014·Science·Sarah K McMenaminDavid M Parichy
Jan 24, 2016·Pigment Cell & Melanoma Research·Andrey FadeevChristiane Nüsslein-Volhard
Dec 30, 2014·Trends in Genetics : TIG·Masakatsu Watanabe, Shigeru Kondo
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Jan 11, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrey FadeevRuth H Palmer
Oct 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth S MoStefania Nicoli
May 25, 2016·Biology Open·Hans Georg FrohnhöferUwe Irion
Mar 6, 2019·Disease Models & Mechanisms·Laura MartoranoFrancesco Argenton
Feb 27, 2020·Proceedings of the National Academy of Sciences of the United States of America·Melissa R McGuirlBjörn Sandstede
Dec 21, 2017·PLoS Biology·Damian Dalle Nogare, Ajay B Chitnis
May 13, 2018·Genes·Verena A Kottler, Manfred Schartl

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Methods Mentioned

BETA
transgenic

Software Mentioned

shd
LAS
rse

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