Irinotecan in the treatment of elderly patients with advanced colorectal cancer

Critical Reviews in Oncology/hematology
Javier SastreEduardo Díaz-Rubio

Abstract

Irinotecan is an active drug in the first and subsequent lines of chemotherapy for patients with advanced colorectal cancer. Frequently, the elderly patients are excluded from receiving irinotecan alone or in combination, and on many occasions these patients receive an initial reduced dose of this drug. This revision has been focused in the role of irinotecan in elderly patients. Data from pharmacokinetic studies, comparative analysis of prospective trials according to age and prospective studies with irinotecan alone or irinotecan-combinations in the elderly have been revised and put into context. Either pharmacokinetic and clinical data suggest that fit elderly patients may tolerate irinotecan as well as the younger population. Response rate and survival achieved in elderly patients with irinotecan combinations seem to be equivalent to that obtained in younger patients. Elderly patients with advanced colorectal cancer should be carefully evaluated in order to be classified as fit or not fit through a comprehensive geriatric assessment. For the group of fit elderly patients, irinotecan may be used as in the younger population.

References

Sep 28, 2000·The New England Journal of Medicine·L B SaltzL L Miller
Jun 19, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E MitryP Rougier
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Javier SastreUNKNOWN Cooperative Group for the Treatment of Digestive Tumors

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Citations

May 19, 2011·The Journal of Pharmacy and Pharmacology·ChunLei LiPing Wang
Aug 15, 2017·Langenbeck's Archives of Surgery·Markus AlbertsmeierJutta Engel
Nov 26, 2015·World Journal of Gastroenterology : WJG·Ken-ichi FujitaYasutsuna Sasaki

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