Irinotecan-induced dysarthria: A case report and review of the literature

Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Krista G RamirezWilliam J Edenfield

Abstract

Irinotecan-induced dysarthria has been reported in the literature, but the underlying mechanism of this neurotoxicity remains unclear. Here, we present a 35-year-old female with metastatic colon cancer who experienced dysarthria during irinotecan infusion. Her symptoms were decreased and eventually eliminated with subsequent increases in infusion time. When the patient returned to original 90 min infusion time, symptoms were significantly reduced in both severity and duration as compared to the first infusion. We suggest infusion time as a potential intervention for patients experiencing dysarthria, and we review the existing literature, explore treatment options, and discuss proposed mechanisms surrounding this unusual adverse drug reaction.

References

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Citations

Apr 27, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Saeedeh Keyvani-GhamsariMaryam Shahhoseini
Jul 28, 2017·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·S S PetersS H Wrzesinski
Mar 23, 2018·Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners·David B ZhenVaibhav Sahai
May 3, 2019·Cancer Biomarkers : Section a of Disease Markers·Dimitra-Ioanna LampropoulouMaria Gazouli
Jul 24, 2020·Oncology and Therapy·Mariagrazia De LisaRossana Berardi

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