IRIS II study: the IRIS II score--assessment of a new clinical algorithm for the classification of insulin resistance in patients with Type 2 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
T ForstAndreas Pfützner

Abstract

With the increasing availability of new drugs for the treatment of insulin resistance in patients with Type 2 diabetes, simple methods for their identification is an important challenge. The aim of our study was to compute a new algorithm for estimating insulin resistance in a routine clinical setting. Clinical data and blood samples were collected from 4265 Type 2 diabetic patients from 149 clinical sites. A clinical algorithm to estimate insulin resistance was developed by stepwise multiple regression analysis. The new generated score was compared with the HOMAIR-score, calculated from fasting insulin and glucose levels measured in a central laboratory. In a subgroup of 48 patients, the score was verified against a frequently sampled intravenous glucose tolerance test with subsequent modified minimal model analysis according to Bergman. Multiple regression analysis revealed fasting blood glucose, BMI, triglycerides and HDL as the most powerful predictors of insulin resistance which were used for further computation of the IRIS II score. A significant overall correlation was found between the HOMAIR-score and the new clinical IRIS II score (r = 0.42; P < 0.0001). Compared with HOMAIR, the new score revealed a specificity of 0....Continue Reading

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Citations

Feb 14, 2006·Diabetes Technology & Therapeutics·Andreas Pfützner, Thomas Forst
May 28, 2008·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Mojca JensterleAndrej Janez
Apr 16, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Jin XuUNKNOWN IRIS Trial Investigators
Sep 30, 2015·Journal of Laboratory Physicians·Happy Chutia, Kyrshanlang G Lynrah
Jun 24, 2009·Critical Care : the Official Journal of the Critical Care Forum·Alexander KochChristian Trautwein
Dec 4, 2004·PLoS Medicine·Michael LehrkeMitchell A Lazar
Apr 30, 2011·Journal of Diabetes Science and Technology·Kunal M SharmaViswanathan Mohan
Apr 29, 2005·Diabetes/metabolism Research and Reviews
Apr 25, 2007·Molecular and Cellular Biology·Dipayan RudraJonathan R Warner

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