Iris transluminance in type 2 diabetes

Acta Ophthalmologica Scandinavica
R Voutilainen-KaunistoM E Teräsvirta

Abstract

Cross-sectional analysis of iris transluminance in type 2 diabetic patients compared with control subjects, all followed in a cohort study. A cohort consisting of a well-characterized group of 82 type 2 diabetic patients were followed for 10 years after diagnosis, as were 125 control subjects. The prevalence of iris transluminance was determined by transscleral transillumination and by grading of black-and-white positive prints at the 10-year examination. The frequency of diabetic retinopathy was prospectively determined by grading of fundus photographs at baseline and after five and 10 years. Iris transluminance was found in 27% of diabetic patients and 8.0% of control subjects (P = 0.001). The diabetic patients with more severe and short-term retinopathy more commonly had abnormal iris transluminance than those with no or only mild retinopathy (P < 0.05). Iris transluminance was not associated with intraocular pressure or glycemic control. In type 2 diabetic patients, abnormal iris transluminance tended to associate with more severe and short-term retinopathy. Therefore we assume that hypoxia is responsible for the defects in the pigment layer of the iris. Thus, abnormal iris transluminance may serve as a marker for rapidly p...Continue Reading

References

Jan 1, 1976·International Ophthalmology Clinics·D D Donaldson
Oct 1, 1988·Diabetologia·G M Kostner, I Karádi
Feb 1, 1970·American Journal of Ophthalmology·M YanoffJ W Berkow
Jan 1, 1971·Acta Ophthalmologica·M S Norn
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Sep 1, 1966·American Journal of Ophthalmology·H S Sugar
Sep 1, 1994·Journal of Internal Medicine·L NiskanenM Uusitupa

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Citations

Sep 13, 2006·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Fion D Bremner, Stephen E Smith
Mar 13, 2009·Clinical & Experimental Ophthalmology·Nuwan Niyadurupola, David C Broadway

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