Irisin ameliorates angiotensin II-induced cardiomyocyte apoptosis through autophagy

Journal of Cellular Physiology
Ru-Li LiWei Jiang

Abstract

Cardiac hypertrophy is the main cause of heart failure and sudden death in patients. But the pathogenesis is unclear. Angiotensin II may contribute to cardiac hypertrophy in response to pressure overload. In angiotensin II-treated cardiomyocytes, there is a larger cross-sectional area, more apoptosis cells, and a reduction of irisin expression. An increase in P62, an autophagy flux index, as well as LC3II, were observed in cardiomyocytes after angiotensin II-induced injury. Surprisely, irisin supplementation increased LC3II expression and decreased P62 expression, consisted of results of RFP-GFP-LC3B adenovirus transfection, and reduced cardiomyocyte apoptosis, meanwhile, the protection of irisin was reversed by the autophagy inhibitor 3-methyladenine. In animal experiments, overexpression of irisin reduced cardiomyocyte apoptosis and alleviated myocardial hypertrophy caused by pressure overload. The above results indicate that irisin-induced protective autophagy and alleviated the apoptosis signaling pathway in cardiomyocytes, consequently reducing cardiomyocyte apoptosis after angiotensin II-induced injury. Hence, increasing irisin expression may be a new way to improve cardiac function and quality of life in patients with ca...Continue Reading

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Citations

Jan 10, 2020·Stem Cells and Development·Tianqi TuYong Jiang
Sep 10, 2019·Aging·Jiahao DuanChun Yang
Sep 27, 2019·Frontiers in Cell and Developmental Biology·Akshay BarejaJames P White
Oct 18, 2020·International Journal of Molecular Sciences·Mirko PesceAntonia Patruno
Jan 4, 2021·Molecular Biology Reports·Jun Ma, Ken Chen
Oct 9, 2021·Journal of the American Heart Association·Jinjuan FuJian Yang

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