Irisin and BDNF serum levels and behavioral disturbances in Alzheimer's disease

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Elisa ContiLucio Tremolizzo

Abstract

Behavioral dysfunctions (BPSD) represent the most important problem in Alzheimer's dementia (AD) management. We assessed the serum levels of two myokines in AD patients, preliminary investigating, as secondary aim, their role as potential biomarkers for agitation/aggression (AA) and aberrant motor behavior (AMB): irisin, since it is able to modify the motor pattern, and BDNF, since it was transcribed following irisin stimulation. Forty AD patients were recruited and characterized according to the expressed neuropsychiatric syndrome. Myokines were measured by ELISA. Irisin serum levels were slightly elevated in AA+ patients (+ 10.0%; p < 0.05) and correlated with the duration of AA (r = 0.74, p < 0.03). BDNF failed to show such differences. We propose that these selected myokines are not useful as surrogate markers for agitation in AD, but might represent interesting secondary outcomes when testing drugs for those BPSD implying elevated motor activity.

References

Mar 15, 2006·International Journal of Geriatric Psychiatry·Guy NagelsPeter Paul De Deyn
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Feb 9, 2013·Dementia and Geriatric Cognitive Disorders·Lucio TremolizzoIldebrando Appollonio
Jul 8, 2014·Frontiers in Cellular Neuroscience·Cristy PhillipsAhmad Salehi
Oct 10, 2014·Dementia and Geriatric Cognitive Disorders Extra·Victor BlonieckiYvonne Freund-Levi
Apr 7, 2015·Neuroscience Letters·Weizhen ZhangMichael Mulholland
Nov 28, 2015·Neuromolecular Medicine·Mohammad Jodeiri FarshbafMohammad Hossein Nasr-Esfahani
Jan 9, 2016·Neuro-degenerative Diseases·Lucio TremolizzoCarlo Ferrarese
Feb 28, 2016·Molecular and Cellular Neurosciences·Alessandro ArosioLucio Tremolizzo
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Jun 15, 2016·Human Psychopharmacology·Elisa ContiCarlo Ferrarese
Nov 6, 2018·Journal of Clinical Medicine·Oh Yoen Kim, Juhyun Song

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Citations

Jul 25, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Elisa ContiLucio Tremolizzo
Jan 9, 2021·Frontiers in Aging Neuroscience·Yaqiang LiuChaoyue Meng
Mar 27, 2021·Neuropathology and Applied Neurobiology·Katie A BretlandChristine M Dengler-Crish

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