Irisin and its relation to insulin resistance and puberty in obese children: a longitudinal analysis

The Journal of Clinical Endocrinology and Metabolism
Thomas ReinehrChristian L Roth

Abstract

Irisin is a recently identified myokine affecting metabolic and glucose homeostasis. However, the role of irisin in obesity and its metabolic consequences are controversial, and data in children are scarce. To study the relationships between irisin, insulin resistance, and puberty before and after weight loss in obese children with and without impaired glucose tolerance. One-year follow-up study in obese children participating in a lifestyle intervention. Primary care. Forty obese children and 20 normal-weight children of similar age, gender, and pubertal stage. A 1-year outpatient intervention program based on exercise, behavior, and nutrition therapy. Fasting serum irisin, weight status (body mass index [BMI] SD score), and the following parameters of the metabolic syndrome: insulin resistance index (homeostasis model of assessment), blood pressure, and lipids. The irisin levels were the highest in obese children with impaired glucose tolerance, followed by obese children with normal glucose tolerance, and levels were lowest in normal-weight children (P < .001). In a multiple linear regression analysis, baseline irisin was significantly associated with pubertal stage, high-density lipoprotein-cholesterol, and homeostasis mode...Continue Reading

Citations

Mar 13, 2016·Lipids in Health and Disease·Nasser M Al-DaghriMajed S Alokail
Jun 18, 2015·Metabolism: Clinical and Experimental·Yoshifumi TsuchiyaKazushige Goto
Jun 9, 2016·Thyroid : Official Journal of the American Thyroid Association·Grigorios PanagiotouChristos S Mantzoros
Aug 20, 2016·Journal of Diabetes and Its Complications·Gönül ÇatlıAyhan Abacı
Jul 30, 2016·PloS One·Lara Pena-BelloFernando Cordido
Jan 24, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Chiara MameliCristiana Perrotta
Jan 25, 2018·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Fatemeh KazeminasabMohammad Hossein Nasr-Esfahani
Oct 12, 2018·Journal of Sports Sciences·Athanasios KabasakalisVassilis Mougios
Oct 20, 2018·Current Diabetes Reports·Thomas Reinehr, Christian Ludwig Roth
Nov 13, 2018·The Journal of Clinical Endocrinology and Metabolism·Alessandro CiresiCarla Giordano
Mar 27, 2019·The Journal of Endocrinology·Fazal WahabRüdiger Behr
Sep 15, 2017·Endocrine Journal·Young Suk ShimIl Tae Hwang
Oct 22, 2016·Diabetes & Metabolism Journal·Yaeko FukushimaYutaka Kimura
Aug 31, 2016·European Journal of Clinical Investigation·Rosa María AgraJohn P H Wilding
Feb 18, 2017·Nature Reviews. Endocrinology·Nikolaos PerakakisChristos S Mantzoros
Sep 24, 2020·Journal of Diabetes Research·Anna S Huerta-DelgadoLeticia Elizondo-Montemayor
Jul 12, 2017·Annals of Pediatric Endocrinology & Metabolism·Sung Eun KimByoung Kyu Suh
Jul 22, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Petra NiklowitzThomas Reinehr
Nov 28, 2018·International Journal of Molecular Sciences·Leticia Elizondo-MontemayorGerardo Garcia-Rivas
Sep 25, 2020·Clinical Epigenetics·Cristina Gallardo-EscribanoM Rosa Bernal-Lopez
Oct 10, 2020·The Journal of Clinical Endocrinology and Metabolism·Esra KutluYaşar Cesur
Aug 18, 2020·Journal of Pediatric Gastroenterology and Nutrition·Cristina Gallardo-EscribanoM Rosa Bernal-Lopez
Mar 21, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Shoujuan ZhengXia Wang
Feb 15, 2021·Reproductive Biology and Endocrinology : RB&E·Yunyao LuoLiangzhi Xu

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