Irisin and the Metabolic Phenotype of Adults with Prader-Willi Syndrome

PloS One
Harry J HirschVarda Gross-Tsur

Abstract

Hyperphagia, low resting energy expenditure, and abnormal body composition contribute to severe obesity in Prader Willi syndrome (PWS). Irisin, a circulating myokine, stimulates "browning" of white adipose tissue resulting in increased energy expenditure and improved insulin sensitivity. Irisin has not been previously studied in PWS. Compare plasma and salivary irisin in PWS adults and normal controls. Examine the relationship of irisin to insulin sensitivity and plasma lipids. A fasting blood sample for glucose, lipids, insulin, leptin, adinopectin, and irisin was obtained from 22 PWS adults and 54 healthy BMI-matched volunteers. Saliva was collected for irisin assay in PWS and controls. Fasting glucose (77 ± 9 vs 83 ± 7 mg/dl, p = 0.004), insulin (4.1 ± 2.0 vs 7.9 ± 4.7 μU/ml, p<0.001), and triglycerides (74 ± 34 vs 109 ± 71 mg/dl, p = 0.007) were lower in PWS than in controls. Insulin resistance (HOMA-IR) was lower (0.79 ± 0.041 vs 1.63 ± 1.02, p<0.001) and insulin sensitivity (QUICKI) was higher (0.41 ± 0.04 vs 0.36 ± 0.03, p<0.001) in PWS. Plasma irisin was similar in both groups, but salivary irisin (64.5 ± 52.0 vs 33.0 ± 12.1ng/ml), plasma leptin (33.5 ± 24.2 vs 19.7 ± 19.3 ng/ml) and plasma adinopectin (13.0 ± 10.8 vs 7...Continue Reading

References

Dec 1, 1996·Metabolism: Clinical and Experimental·D P SchusterW B Zipf
May 26, 1998·Annals of the New York Academy of Sciences·P S Hart
Nov 15, 2006·American Journal of Medical Genetics. Part a·Merlin G ButlerJoseph E Donnelly
Sep 11, 2008·European Journal of Human Genetics : EJHG·Suzanne B Cassidy, Daniel J Driscoll
Apr 10, 2009·The New England Journal of Medicine·Aaron M CypessC Ronald Kahn
Oct 22, 2010·The Journal of Clinical Endocrinology and Metabolism·Andrea M HaqqMichael Freemark
Apr 6, 2011·American Journal of Medical Genetics. Part a·Jennifer L MillerDaniel J Driscoll
Jun 8, 2012·Archives of Oral Biology·Ronnaug SaevesHilde Nordgarden
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·José María Moreno-NavarreteJosé Manuel Fernández-Real
Sep 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Kyung Hee ParkChristos S Mantzoros
Nov 6, 2013·European Journal of Clinical Investigation·Nasser M Al-DaghriGeorge P Chrousos
May 2, 2014·The Journal of Clinical Endocrinology and Metabolism·Hae Yoon ChoiKyung Mook Choi
May 28, 2014·International Journal of Endocrinology·María PardoFelipe F Casanueva
Jul 26, 2014·Metabolism: Clinical and Experimental·Grigorios PanagiotouChristos S Mantzoros
Mar 10, 2015·Scientific Reports·Elke AlbrechtSteffen Maak

❮ Previous
Next ❯

Citations

May 14, 2016·Metabolism: Clinical and Experimental·Shanhu QiuUwe Schumann
May 24, 2016·EBioMedicine·Hong TangWeizhen Zhang
Oct 24, 2018·Endocrine Connections·Devis PascutAlessandro Sartorio
Nov 7, 2019·American Journal of Medical Genetics. Part a·Harry J HirschNaama Constantini
Jan 25, 2020·Scientific Reports·Stefania MaiPaolo Marzullo
Feb 8, 2020·Current Diabetes Reports·Antonino Crinò, Graziano Grugni
Mar 4, 2021·Journal of Endocrinological Investigation·M F FaienzaM Grano
Aug 5, 2021·Orphanet Journal of Rare Diseases·Harry J Hirsch, Varda Gross-Tsur

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
ELISA

Software Mentioned

QUICKI

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

© 2021 Meta ULC. All rights reserved