Irisin as an early marker for predicting gestational diabetes mellitus: a prospective study

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Onur ErolNecat Yılmaz

Abstract

The objective of this study is to evaluate maternal serum irisin levels in the first and second trimesters of pregnancy in women diagnosed with and without gestational diabetes mellitus (GDM). We performed a prospective, nested case-control study in 258 pregnant women who were enrolled at the time of the first prenatal visit (6-11th weeks of gestation) and followed until delivery. Among the entire population, we selected 20 women who subsequently developed GDM and 30 women with uneventful pregnancies. Blood samples were collected once from each participant at 6-11th weeks of gestation during the fetal viability scan and at 24-28th weeks of gestation during screening for GDM. In the first trimester, irisin levels were significantly lower in women who later developed GDM (median = 453 ng/mL, range: 257-811 ng/mL) than in controls (median = 721 ng/mL, range: 700-786 ng/mL). In the second trimester, the difference in irisin levels between the GDM group (median = 749 ng/mL; range: 456-910 ng/mL) and controls (median = 757 ng/mL; range: 703-898 ng/mL) was not statistically significant. Irisin may be a useful biomarker in early pregnancy to predict the development of GDM.

References

Jul 25, 2008·Nature·Christoph Handschin, Bruce M Spiegelman
Feb 4, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·E Albert Reece
Jan 10, 2012·Diabetes/metabolism Research and Reviews·Janine Malcolm
Feb 2, 2013·Diabetes Research and Clinical Practice·Yeon-Kyung ChoiKeun-Gyu Park
Feb 26, 2013·The Journal of Clinical Endocrinology and Metabolism·José María Moreno-NavarreteJosé Manuel Fernández-Real
Apr 18, 2013·PloS One·Arturo Roca-RivadaMaría Pardo
Apr 27, 2013·Journal of Diabetes and Its Complications·Jian-Jun LiuSu Chi Lim
Dec 18, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·P M Catalano
Jan 9, 2014·American Journal of Physiology. Endocrinology and Metabolism·Milan K PiyaPhilip G McTernan
Jan 23, 2014·Diabetes Research and Clinical Practice·Mehmet Aytac YukselRiza Madazli
Jan 25, 2014·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·F Sanchis-GomarC Perez-Quilis
Mar 19, 2014·The Journal of Clinical Endocrinology and Metabolism·María F GarcésJorge E Caminos
May 23, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Mariusz KuzmickiJacek Szamatowicz
May 28, 2014·International Journal of Endocrinology·María PardoFelipe F Casanueva
Aug 13, 2014·European Journal of Clinical Investigation·Carolina Gutierrez-RepisoEduardo Garcia-Fuentes
Apr 1, 2015·Molecular Endocrinology·Hye Jeong LeeHyeon Soo Kim

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Citations

Apr 17, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·G de GennaroC Bianchi
Feb 18, 2017·Nature Reviews. Endocrinology·Nikolaos PerakakisChristos S Mantzoros
May 18, 2020·Endocrinology·Brooke ArmisteadHamid-Reza Kohan-Ghadr
Nov 25, 2017·Endocrine·Stergios A PolyzosChristos S Mantzoros
Jul 13, 2018·Disease Markers·Tereza PavlovaJulie Bienertova-Vasku
Sep 18, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Dan ShanLi Zou
Dec 17, 2020·International Journal of Molecular Sciences·Paweł GutajEwa Wender-Ozegowska
Mar 18, 2021·Zeitschrift für Geburtshilfe und Neonatologie·Taylan Onat, Nihal Inandiklioglu

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