Irisin Maternal Plasma and Cord Blood Levels in Mothers with Spontaneous Preterm and Term Delivery

Disease Markers
Tereza PavlováJulie Bienertová-Vašků

Abstract

Irisin, an adipomyokine identified in 2012, has been investigated in association with common pregnancy complications, including gestational diabetes mellitus, preeclampsia, and intrauterine growth restriction. The objective of this study is to examine the potential role of irisin in preterm birth (PTB) by comparing its level between mothers with term and preterm labor. Maternal peripheral blood and cord blood samples were collected from 30 mothers who delivered prematurely and from 35 mothers who delivered at term. Irisin concentrations were measured in all samples using ELISA, and four common single nucleotide polymorphisms in the irisin gene were determined (rs16835198, rs726344, rs3480, and rs1746661). Univariable and multivariable regression modeling was applied to evaluate maternal and cord blood irisin concentrations in relation to preterm/term labor. Irisin concentration in umbilical cord blood was found to be associated with PTB in the univariable model (p = 0.046). On the other hand, no differences in maternal blood irisin levels between mothers with preterm and term deliveries were established. To the best of our knowledge, this is the first study determining irisin levels in term and preterm deliveries in maternal pe...Continue Reading

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Citations

Feb 6, 2020·Journal of Cellular Physiology·Sascha DrewloHamid-Reza Kohan-Ghadr
May 18, 2020·Endocrinology·Brooke ArmisteadHamid-Reza Kohan-Ghadr
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Jan 11, 2022·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kumar VivekSeshadri Reddy Varikasuvu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

R
Primer3Plus

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