Irisin promotes cardiac progenitor cell-induced myocardial repair and functional improvement in infarcted heart

Journal of Cellular Physiology
Yu Tina ZhaoTing C Zhao

Abstract

Irisin, a newly identified hormone and cardiokine, is critical for modulating body metabolism. New evidence indicates that irisin protects the heart against myocardial ischemic injury. However, whether irisin enhances cardiac progenitor cell (CPC)-induced cardiac repair remains unknown. This study examines the effect of irisin on CPC-induced cardiac repair when these cells are introduced into the infarcted myocardium. Nkx2.5+ CPC stable cells were isolated from mouse embryonic stem cells. Nkx2.5 + CPCs (0.5 × 10 6 ) were reintroduced into the infarcted myocardium using PEGlylated fibrin delivery. The mouse myocardial infarction model was created by permanent ligation of the left anterior descending (LAD) artery. Nkx2.5 + CPCs were pretreated with irisin at a concentration of 5 ng/ml in vitro for 24 hr before transplantation. Myocardial functions were evaluated by echocardiographic measurement. Eight weeks after engraftment, Nkx2.5 + CPCs improved ventricular function as evident by an increase in ejection fraction and fractional shortening. These findings are concomitant with the suppression of cardiac hypertrophy and attenuation of myocardial interstitial fibrosis. Transplantation of Nkx2.5 + CPCs promoted cardiac regeneration ...Continue Reading

References

May 10, 2001·Journal of Molecular and Cellular Cardiology·M ZhangC E Murry
Jul 19, 2001·Annals of the New York Academy of Sciences·D OrlicP Anversa
Feb 20, 2002·Journal of Molecular and Cellular Cardiology·Jochen Müller-EhmsenLarry Kedes
Jan 9, 2003·Lancet·Christof StammGustav Steinhoff
Oct 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Hidemasa OhMichael D Schneider
Feb 11, 2005·Nature·Karl-Ludwig LaugwitzKenneth R Chien
Feb 28, 2006·Tissue Engineering·Ge ZhangLaura Suggs
Jan 24, 2007·Transplant International : Official Journal of the European Society for Organ Transplantation·Dingguo ZhangKejiang Cao
Feb 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jeannette NussbaumCharles E Murry
Nov 26, 2008·Circulation Research·Massimiliano GnecchiVictor J Dzau
Nov 3, 2009·Cell Transplantation·Ming ZhaoJohn Lough
Mar 31, 2010·Cell Transplantation·Jason WestrichGyongyi Molnar
Jul 8, 2010·Annual Review of Cell and Developmental Biology·Kiran MusunuruKenneth R Chien
Aug 31, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Dongsheng ZhangYigang Wang
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Zhengxian TaoHua Su
Mar 1, 2012·Journal of Diabetes·Fabian Sanchis-GomarJosé L García-Giménez
Oct 2, 2012·The Journal of Biological Chemistry·Ling ZhangTing C Zhao
Apr 18, 2013·PloS One·Arturo Roca-RivadaMaría Pardo
Apr 27, 2013·Journal of Diabetes and Its Complications·Jian-Jun LiuSu Chi Lim
May 15, 2013·Metabolism: Clinical and Experimental·Stergios A PolyzosChristos S Mantzoros
May 15, 2013·Journal of Hepatology·Hui-Jie ZhangXiao-Ying Li
Sep 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Kyung Hee ParkChristos S Mantzoros
Sep 26, 2013·European Journal of Endocrinology·Maria T VamviniChristos S Mantzoros
Mar 1, 2014·Peptides·Tuncay KulogluSuleyman Aydin
May 20, 2014·European Heart Journal·Philippe MenaschéJérôme Larghero
Jun 20, 2014·American Journal of Physiology. Cell Physiology·Ling X ZhangTing C Zhao
Mar 31, 2015·Annals of Clinical Biochemistry·Wenchao HuWenhui Wang
Apr 29, 2015·Cellular Signalling·Min-Jung ParkSoo-Hyun Park
Aug 1, 2015·Journal of Molecular and Cellular Cardiology·Di ZhuLing Tao
Jun 10, 2016·Journal of Cellular Physiology·Nevena JeremicSuresh C Tyagi

❮ Previous
Next ❯

Citations

May 8, 2019·Acta Pharmacologica Sinica·Qiao LiaoWei Eric Wang
Jan 9, 2021·Frontiers in Aging Neuroscience·Yaqiang LiuChaoyue Meng
Mar 14, 2021·Stem Cell Research & Therapy·Zhuoqun FangXiaosong Chen
Apr 4, 2021·International Journal of Environmental Research and Public Health·Pedro L CosioMireia Pelaez
Oct 9, 2021·Journal of the American Heart Association·Jinjuan FuJian Yang
Jul 24, 2021·Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation·Teresa ArcidiaconoGiuseppe Vezzoli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cardiomegaly

Cardiomegaly, known as an enlarged heart, is a multifactorial disease with different pathophysiological mechanisms. Hypertension, pregnancy, exercise-induced and idiopathic causes are some mechanisms of cardiomegaly. Discover the latest research of cardiomegaly here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Cardiac Regeneration

Cardiac regeneration enables the repair of irreversibly damaged heart tissue using cutting-edge science, including stem cell and cell-free therapy. Discover the latest research on cardiac regeneration here.